Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor (AR), and stimulates growth in prostate cancer cells. The purpose of this study is to further determine the potential role of Vav3 in prostate cancer development in genetically engineered mouse model. We generated Vav3 transgenic mice by targeted overexpression of a constitutive...

introduction: 18f-choline pet-ct is an increasingly used technique in patients with prostate cancer. the main indication is to localise the disease in patients with biochemical recurrence. to accurately interpret 18f-choline pet, knowledge of normal tracer distribution is paramount. the aim of this study was to describe the normal distribution pattern of 18f-choline by measuring the maximum sta...

The early detection of prostate cancer plays a significant role in the success of treatment and outcome. To detect prostate cancer, imaging modalities such as TransRectal UltraSound (TRUS) and Magnetic Resonance Imaging (MRI) are relied on. MRI images are more comprehensible than TRUS images which are corrupted by noise such as speckles and shadowing. However, MRI screening is costly, often una...

PURPOSE Prostate gland segmentation is a critical step in prostate radiotherapy planning, where dose plans are typically formulated on CT. Pretreatment MRI is now beginning to be acquired at several medical centers. Delineation of the prostate on MRI is acknowledged as being significantly simpler to perform, compared to delineation on CT. In this work, the authors present a novel framework for ...

PURPOSE Accurate segmentation and volume estimation of the prostate gland in magnetic resonance (MR) and computed tomography (CT) images are necessary steps in diagnosis, treatment, and monitoring of prostate cancer. This paper presents an algorithm for the prostate gland volume estimation based on the semiautomated segmentation of individual slices in T2-weighted MR and CT image sequences. M...

conclusions lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. this mixture gel is safe, easy to administer and well accepted by patients. results the mean of visual analog pain scale was 4.5 in group a, 3.5 in group b, and 2.0 in group c duri...

background: to correct patient positioning errors (setup errors) during prostate cancer treatment using epid and fiducial gold markers, to improve the accuracy of the dose delivery in these patients. materials and methods: fifteen patients with localized prostate carcinoma after implantation of fiducial gold markers in their prostate gland underwent the five-field imrt planning technique. the p...

Salivary, mammary and prostate glands are sex hormone-dependent organs sharing common aspects in structure, hormonal responsiveness and tumor histopathology. Salivary tumors (especially the malignant types) are not as frequent as mammary and prostate neoplasias. Hence, prognosis of some salivary tumors is not always efficient. Here, we review the oncology of salivary gland and its putative rela...