نتایج جستجو برای: prostaglandin e

تعداد نتایج: 1038915  

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992
R P Ryseck C Raynoschek H Macdonald-Bravo K Dorfman M G Mattéi R Bravo

We have characterized a growth factor-inducible gene, pghs-B, isolated by differential screening of a lambda complementary DNA library from RNA of serum-stimulated NIH 3T3 cells which encodes a 604-amino acid protein presenting high similarity with prostaglandin G/H synthase (PGHS). Induction of both pghs-B mRNA and protein is rapid and remains at high levels for several hours. The increase in ...

Journal: :The Journal of Experimental Medicine 1979
T Yoneda G R Mundy

The production of osteoclast-activating factor (OAF) by normal human peripheral blood leukocytes stimulated by phytohemagglutinin was inhibited by a series of structurally unrelated inhibitors of prostaglandin synthetase. Inhibition of OAF production by these agents was reversed by adding prostaglandins of the E series back to the leukocyte suspension. These results indicate that prostaglandin ...

Journal: :The Biochemical journal 1985
B Leighton L Budohoski F J Lozeman R A Challiss E A Newsholme

Prostaglandins E1 and E2 increased the sensitivity of glycolysis to insulin in the isolated stripped soleus muscle of the rat, but prostaglandin F2 alpha had no effect. Indomethacin, which inhibits prostaglandin formation, markedly decreased the sensitivity of glycolysis to insulin. These findings suggest that prostaglandins of the E series increase the sensitivity of muscle glycolysis to insul...

Journal: :Stroke 1984
A M Rodrigues M E Gerritsen

Prostaglandin release from microvessels isolated from the rabbit cerebral cortex was determined under three different atmospheric conditions: 100% O2 ("O2") room air, and 95% N2:5% CO2 ("N2-CO2"). Initial studies with homogenates prepared from rabbit cerebral microvessels (RCMV) indicated two pathways of enzymatic PGH2 transformation, namely PGI2 synthase and GSH-dependent PGH-PGE isomerase. We...

2016
Shahram Jevin Poureetezadi Christina N Cheng Joseph M Chambers Bridgette E Drummond Rebecca A Wingert

Kidney formation involves patterning events that induce renal progenitors to form nephrons with an intricate composition of multiple segments. Here, we performed a chemical genetic screen using zebrafish and discovered that prostaglandins, lipid mediators involved in many physiological functions, influenced pronephros segmentation. Modulating levels of prostaglandin E2 (PGE2) or PGB2 restricted...

Journal: :Cell 1997
Yoshihide Kanaoka Hideo Ago Eiji Inagaki Toyomichi Nanayama Masashi Miyano Reiko Kikuno Yutaka Fujii Naomi Eguchi Hiroyuki Toh Yoshihiro Urade Osamu Hayaishi

Hematopoietic prostaglandin (PG) D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells. We isolated a cDNA for the rat enzyme, crystallized the recombinant enzyme, and determined the three-dimensional structure of the enzyme complexed with glutathione at 2.3 A resolution. The enzyme is the first member of the sigma class glutathione...

2016
Grace J. Young Nicole Harter Minnelly Luu

CHD: congenital heart disease ECMO: extracorporeal membrane oxygenation PGE1: prostaglandin E

2013
Amanda M. Nelson Dorothy E. Loy John A. Lawson Adiya S. Katseff Garret A. FitzGerald Luis A. Garza

Prostaglandins (PGs) are key inflammatory mediators involved in wound healing and regulating hair growth; however, their role in skin regeneration after injury is unknown. Using wound-induced hair follicle neogenesis (WIHN) as a marker of skin regeneration, we hypothesized that PGD2 decreases follicle neogenesis. PGE2 and PGD2 were elevated early and late, respectively, during wound healing. Th...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید