conclusions considering that no significant difference was found in the proven vitamin a side effects, due to the increase in crp, frequent clinical and biochemical controls are required along with vitamin a supplementation. patients and methods this study was a double blind randomized clinical trial. in the main study, vitamin a (as retinyl palmitate) was given to 35 multiple sclerosis (ms) pa...

The common consideration on economic model is that there is knowledge about the risk of occurrence of an assignable cause and the various cost parameters that does not always adequately describe what happens in practice. Hence, there is a need for more realistic assumptions to be incorporated. In order to reduce cost penalties for not knowing the true values of some parameters, this paper aims ...

this paper uses the weighted l$_1-$norm to propose an algorithm for finding a well-dispersed subset of non-dominated solutions of multiple objective mixed integer linear programming problem. when all variables are integer it finds the whole set of efficient solutions. in each iteration of the proposed method only a mixed integer linear programming problem is solved and its optimal solutions gen...

This paper considers a bi-level hazmat transportation network design problem in which hazmat shipments have to be transported over a road network between specified origin-destination points. The bi-level framework involves a regulatory authority and hazmat carriers. The control variables for the regulatory authority are locations of hazmat response teams and which additional links to include fo...

The accelerated changes on our planet have led to a growing interest in climate change and its consequences: natural hazards adverse socio-economic impacts. However, the development of research proliferation datasets require an integrated efficient approach analysis, investigation, visualization atmospheric meteorological data. Thus, we propose literature review existing systems viewing phenome...

In this paper, we consider a flow shop scheduling problem with availability constraints (FSSPAC) for the objective of minimizing the makespan. In such a problem, machines are not continuously available for processing jobs due to preventive maintenance activities. We proposed a mixed-integer linear programming (MILP) model for this problem which can generate non-permutation schedules. Furthermor...

We propose a novel approach for solving the problem of coevolution between metamodels and OCL constraints. Unlike existing solutions, our approach does not rely on predefined update rules and explicit tracking of high level changes to the metamodel. Rather, we pose it as a multi-objective optimization problem, exploring the space of possible OCL modifications to identify solutions that (a) do n...

Abstract Geoconservation consists of the selection and conservation geodiversity elements that have significant heritage value. The management geological sites is based on specific procedures to ensure public use minimize adverse impacts. evaluation carrying capacity a tool helps define acceptable limits visitation, without causing impacts integrity these sites. This work presents review concep...

When dealing with real data, clustering becomes a very complex problem, usually admitting many reasonable solutions. Moreover, even if completely different, such solutions can appear almost equivalent from the point of view of classical quality measures such as the distortion value. This implies that blind optimisation techniques alone are prone to discard qualitatively interesting solutions. I...

Optimizing gate scheduling at airports is an old, but also a broad problem. The main purpose of this problem is to find an assignment for the flights arriving at and departing from an airport, while satisfying a set of constraints.A closer look at the literature in this research line shows thatin almost all studies airport gate processing time has been considered as a fix parameter. In this res...