The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propofol for prolonged periods. In vivo and in vitro evidence suggests that the propofol toxicity is r...

Background: Vascular Endothelial Growth Factor (VEGF) is one of the most critical factors that stimulate angiogenesis in colorectal cancer patients. The Matrix Metalloproteinases (MMPs) are involved degeneration extracellular matrix and regulation cell-matrix interactions. MMP-3 plays an important role metastasis cancer. Our aim was to investigate effect propofol on VEGF plasma levels Methods: ...

We have measured whole blood concentrations and pharmacokinetics of propofol administered as a constant rate infusion during cardiac surgery. Ten patients undergoing elective cardiac surgery involving cardiopulmonary bypass (seven myocardial revascularization and three aortic valve surgery) received a continuous infusion of propofol 4 mg kg-1 h-1 to supplement alfentanil analgesia. Whole blood ...

Background: Propofol may be an appropriate agent for induction and maintenance of anesthesia in obese patients. However, there is a controversy regarding the propofol dose in such patients. This study was done to evaluate propofol dose, based on total body weight (TBW), in obese compared to non-obese patients. Methods: Fifty ASA I-II adult patients, who underwent different surgical procedures, ...

BACKGROUND the present study was designed to compare the efficacy, tolerability and safety of dexmedetomidine and fentanyl when combined with propofol during extracorporeal shock wave lithotripsy in children. METHODS fifty children aged 3-8 years, the American Society of Anesthesiologists status I and II, scheduled for elective extracorporeal shock wave lithotripsy were randomly allocated to ...

BACKGROUND Many pathophysiologic alterations in patients with major burns can cause changes in the response of propofol. The aim of this study is to determine the appropriate induction dose of propofol using a slow infusion rate for major burn patients to obtain desirable sedation and hypnotic conditions with minimal hemodynamic changes. METHODS 45 adults with major burns and who were electiv...

We read with interest the comprehensive review of Krajčová et al. [1] on propofol infusion syndrome (PRIS). Of particular importance is the high (51 %!) associated mortality which is mainly determined by cardiac failure, therapy-resistant bradyarrhythmia, metabolic acidosis, and rhabdomyolysis [1]. The authors provide a detailed insight on the pathophysiologic mechanism(s) underlying PRIS but d...

Background Propofol is a widely known, commonly used drug. Complications can occur with the use of this drug, including propofol-related infusion syndrome (PRIS). PRIS, in the obstetric population, has not been documented; however, we report a case of a patient who developed PRIS after an emergent cesarean delivery of a preterm infant. Case Study A 35-year-old multigravida woman presented compl...

AIM To evaluate the impact of bispectral index (BIS) monitoring on the consumption of propofol and recovery from anesthesia compared to the standard clinical practice in children. BACKGROUND Titrating propofol administration using BIS reduces its requirement and shortens the recovery from anesthesia in adults. However, there is still mixed evidence for utility of anesthesia depth monitors in ...