BACKGROUND/AIMS Patients with rhegmatogenous retinal detachment (RRD) who develop postoperative proliferative vitreoretinopathy (PVR) have been found to have higher preoperative laser flare values than patients with RRD who do not develop this complication. Measurement of laser flare has therefore been proposed as an objective, rapid and non-invasive method for identifying high-risk patients. T...

The results are presented of a migration assay of scleral fibroblasts to 25% diluted vitreous samples from 27 patients with complex retinal detachments divided into three groups: group 1, no proliferative vitreoretinopathy (PVR); group 2, early PVR; and group 3, advanced PVR. There was a statistically significantly greater migration with vitreous samples from group 3 than with group 1 (p less t...

AIMS To determine whether it is necessary to support inferior retinal breaks with a scleral explant during pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RD). METHODS A prospective study was carried out on nine eyes of nine consecutive patients undergoing PPV for primary RD with associated inferior retinal breaks and no significant proliferative vitreoretinopathy. RESULT...

BACKGROUND Proliferative vitreoretinopathy (PVR) is the commonest cause of late anatomical failure in rhegmatogenous retinal detachment. Visual and anatomical outcomes remain poor despite advances in vitreoretinal surgical techniques with reported primary failure rates of up to nearly 50%. Numerous adjunctive medications have been evaluated in clinical trials with no agent gaining widespread ac...

METHOD Prospective observational study including 10 patients (age range: 27-74 years) with recurrent retinal detachment (RD) and proliferative vitreoretinopathy (PVR) and 2.8 mean unsatisfactory previous surgeries. Densiron® was injected in all patients, with surgical retinectomy being required in 70% of them. Minimum follow-up time was 12 months. RESULTS The mean length of time before Densir...

The effect of 3,3'-iminodipropionitrile (IDPN) on experimental intravitreal proliferation in albino rabbits was studied by light and electron microscopy. About 2.5 x 10(5) tissue cultured fibroblasts were injected into the vitreous cavity of albino rabbits. Immediately after the injection, phosphate-buffered solution (PBS) or IDPN was injected into the vitreous cavity. Four weeks later, tractio...

Seventy-five cases of total retinal detachment complicated by the more advanced grades (grades C and D) of proliferative vitreoretinopathy were treated with scleral buckling, vitrectomy, and air-fluid exchange. The overall reattachment rate was 56%, ranging from 100% in grade C-1 to 26% in grade D-3. The postoperative visual acuity was 6/120 or better in 48% of the 42 eyes in which the retina w...