Background: A growing body of literature has revealed the effective role of miR-34a, as a tumor suppressor and regulator of expression of multiple targets in tumorigenesis and cancer progression. This study aimed at evaluating the potential effects of miR-34a alone or in combination with paclitaxel on breast cancer cells. Methods: After miR-34a transduction by lentiviral vectors in two MCF-7 an...

The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...

the ultimate goal of the periodontal treatments is a regeneration of periodontium. recently, laser irradiations are commonly used to improve wound repair. because of many controversies about the effects of laser on soft tissue regeneration, more in vitro studies are still needed. the aim of the present in vitro study was to compare the effects of different doses of er:yag (erbium-doped:yttrium,...

objective: embryonic cerebrospinal fluid (e-csf) has an important role in development of embryonic and adult brain. proteomic analysis suggests that this fluid has many morphogenes and cytokines that alter in time and space throughout embryonic life. the aim of this study was to evaluate the developmental effect of embryonic csf on proliferation and differentiation of neuroprogenitor cells in d...

Background  Recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (LLLT). The aim of this study was to determine whether LLLT could induce a bio-stimulatory effects on human gingival fibroblasts (HGF3-PI 53). Therefore, the effect of laser irradiation on human gingival cell proliferation and collagen type I gene ...

Abstract The biodegradable composites were prepared by melt blending of chitosan (CS) and poly(butyleneadipate- co -terephthalate) (PBAT). By utilizing Fourier transformed infrared spectroscopy, scanning electron microscopy-energy dispersive mechanical properties analysis, water contact angle measuring, differential calorimetry, thermogravimetric it was demonstrated that the CS PBAT-CS10 compos...

MiR-520d-3p has recently been reported to have anti-tumor function in several cancers, including glioma and gastric cancer. However, the biological its mechanism of action remain unclear cervical cancer (CC). In this study, we observed that miR-520d-3p expression was lowly expressed CC specimens compared with adjacent normal using reverse transcription quantitative PCR. Moreover, low correlated...

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. Preparation of cycloartane derivatives, 3, 24-O-diacetyl-cycloart-25-en as compound 3 and 3-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The ...