Objective(s): To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs).Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observ...

bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...

the radioprotective effects of vitamin c and famotidine were investigated using the micronucleus test for anticlastogenic and cell proliferation activity. various doses of vitamin c and famotidine were administered intraperitoneally 2 h before 2gy gamma irradiation to nmri adult male mice. frequency of micronuclei in 1000 pces (mnpces) were scored for each sample. cell proliferation ratio (pce/...

objective: the development of combining mesenchymal stem cells (mscs) with surface modified three-dimensional (3d) biomaterial scaffold provides a desirable alternative for replacement of damaged and diseased tissue. nanofibrous scaffolds serve as suitable environment for cell attachment and proliferation due to their similarity to the physical dimension of the natural extracellular matrix. in ...

In this study, we have investigated the proliferative response of human dermal fibroblasts isolated from normal and psoriatic individuals to different cytokines. We found that IL-1, TNF (α) and EGF are stimulatory whereas IFN « and 1 both showed inhibitory activity on fibroblast proliferation. IL-6 a more recently described cytokine, showed no detectable effects on cell proliferation. Inve...

Background  Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis. Sound wave especially low intensity ultrasound (LIUS) can be effective on increasing the number of cells. In this study we investigated the effect of LIUS stimulation on mouse SSCs proliferation and colonization. Methods: Isolated SSCs from neonate mice cultured in DMEM culture medium with 10% Fetal Bovine S...

in the framework of non-proliferation treaty (npt) it has been enumerated three objectives as follow: 1) peaceful use of nuclear energy; 2) non-proliferation of nuclear weapons and 3) nuclear disarmament. the writers in this article have studied and analyzed multilateral aspects of the right of peaceful use of nuclear energy, and interpretation of some npt articles (1, 2 and 4).in the conclusio...

background  recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (lllt). the aim of this study was to determine whether lllt could induce a bio-stimulatory effects on human gingival fibroblasts (hgf3-pi 53). therefore, the effect of laser irradiation on human gingival cell proliferation and collagen type i gene e...

Prostate cancer remains a major public health problem worldwide. Imaging plays an important role in the assessment of disease at all its clinical phases, including staging, restaging after definitive therapy, evaluation of therapy response, and prognostication. Positron emission tomography with a number of biologically targeted radiotracers has been demonstrated to have potential diagnostic and...