STUDY OBJECTIVE To evaluate experience using a therapeutic trial of proton-pump inhibitor therapy with or without a prokinetic agent in diagnosis and treatment of gastroesophageal reflux disease (GERD)-related cough. DESIGN A review of experience with 214 patients with cough of > or = 3 weeks referred over 3.5 years. An anatomic diagnostic protocol was used to identify and treat those with GE...

BACKGROUND Concerned with the rising costs of its drug programs for seniors and social-assistance recipients, the government of Newfoundland and Labrador requested physicians and pharmacists at the Memorial University of Newfoundland, and members of the Newfoundland and Labrador Medical Association and the Newfoundland Pharmaceutical Association to provide guidance to the health care community ...

OBJECTIVE To review the human nutrition in the critically ill patient in a three-part presentation. DATA SOURCES Articles and published peer-review abstracts and a review of studies reported and identified through a MEDLINE search of the English language literature on enteral nutrition. SUMMARY OF REVIEW Enteral nutrition is indicated in the critically ill patient when there is an inability...

Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates. The main goals infantile GERD treatment are maintaining clinical recovery, sufficient growth, and preventing recurrence rate related problems. Acid-suppressive therapy including H2RAs PPIs basic pharmacologic for adult pediatric GERD. more effective than treatment. Neonatal remains a difficult entity to defin...

We describe a case of systemic lupus erythematosus (SLE) with enteritis and peritonitis who later developed pneumatosis cystoides intestinalis (PCI). A 35-year-old woman with SLE relapsed with enteritis and peritonitis. Prednisolone (PSL) effectively improved her symptoms. However, 6 weeks later, she developed PCI. Tapering of PSL, administration of intravenous cyclophosphamide, prokinetic agen...

The effect of cisapride, a new gastrointestinal prokinetic agent, on the transit of a standard meal through the stomach, small intestine and colon was studied in 10 normal subjects. Cisapride had no significant effect on gastric emptying but decreased mouth to caecum transit time (p less than 0.01). Stool weight and frequency were not significantly increased but the time for the first appearanc...

Etiologically, gastroesophageal reflux disease (GERD) can be regarded as motility disorder: Although blocking acid is effective in the treatment of GERD, it does not overcome the underlying pathologic factors that allow acid, pepsin, and bile to reflux into the esophagus. Prokinetic agents address the upper gastrointestinal motility disturbances contributing to GERD and, thus, have an important...