نتایج جستجو برای: progeroid appearance
تعداد نتایج: 87138 فیلتر نتایج به سال:
Segmental progeroid syndromes are a group of disorders with multiple features resembling accelerated aging. Adult-onset Werner syndrome (WS) and childhood-onset Hutchinson-Gilford progeria syndrome are the best known examples. The discovery of genes responsible for such syndromes has facilitated our understanding of the basic mechanisms of aging as well as the pathogenesis of other common, age-...
Further expanding the major findings of the landmark study by Harrison and colleagues showing that late-life pharmacological inhibition of the enzyme mammalian Target Of Rapamycin (mTOR) –a conserved integrator of nutrient and growth factor signaling-is sufficient to significantly extend lifespan in mice on rapamycin feeding [1], Selman and colleagues have recently revealed that loss of the rib...
Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been established. Here we report that Spartan insufficiency in mice causes chromosomal instability, cellular senescence a...
This study uses a door-to-door fund-raising field experiment to explore the returns to physical appearance on fund-raising success. Interestingly, blonde females earn more on average than brunette counterparts. However, the returns to physical appearance depend critically on the race of a potential donor. © 2008 Elsevier B.V. All rights reserved.
This article addresses the issue of expressive face modelling using an active appearance model for facial expression recognition and synthesis. We consider the six universal emotional categories namely joy, anger, fear, disgust, sadness and surprise. After a description of the active appearance model (computed with 3 or only one PCA), we address the active appearance model contribution to autom...
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