نتایج جستجو برای: procoagulant activity

تعداد نتایج: 1135551  

2017
Julie Helms Raphaël Clere-Jehl Elsa Bianchini Pierrick Le Borgne Mélanie Burban Fatiha Zobairi Jean-Luc Diehl Lelia Grunebaum Florence Toti Ferhat Meziani Delphine Borgel

BACKGROUND Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoagulability. We aimed at determining whether recombinant human thrombomodulin (rhTM) could control exaggerated immunothrombosis by studying procoagulant responses, fibrinolysis a...

Journal: :Blood 2015
Katrin F Nickel Göran Ronquist Florian Langer Linda Labberton Tobias A Fuchs Carsten Bokemeyer Guido Sauter Markus Graefen Nigel Mackman Evi X Stavrou Gunnar Ronquist Thomas Renné

Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the intrinsic coagulation pathway factor XI. Prostate cancer cells and secreted prost...

Journal: :Journal of clinical pathology 1983
S Cortellazzo P Viero T Barbui M Colucci N Semeraro

Chronic lymphocytic leukaemia (CLL) is associated with a low incidence of thrombotic complications, or disseminated intravascular coagulation (DIC), or both, despite the frequent occurrence of severe infections. We have investigated the capacity of blood mononuclear cells to produce procoagulant activity when stimulated with bacterial endotoxin in 16 patients with untreated chronic lymphocytic ...

Journal: :Asian Journal of Medical Sciences 2023

We report a case of Crohn’s disease (CD) presenting as thromboembolic middle cerebral artery stroke due to left ventricular (LV) thrombus in 50-year-old lady. The proinflammatory and procoagulant state reported CD seems responsible for this. patient was managed with conservative treatment, but she died quickly. findings highlight the rare occurrence LV well need aggressive control activity dise...

Journal: :Blood 1983
D M Komp L P Clyne E Sullivan

G RAEBER AND STUART’ reported an increase in procoagulant activity in the cerebrospinal fluid (CSF) of children with acute lymphoblastic leukemia (ALL) following prophylactic central ncrvous system (CNS) treatment with cranial radiation and intrathecal methotrexate. They postulated that the shortening of the plasma recalcification time (PRT) reflected the presence of brain phospholipid released...

Journal: :The Journal of Experimental Medicine 1985
D M Stern I Bank P P Nawroth J Cassimeris W Kisiel J W Fenton C Dinarello L Chess E A Jaffe

Interleukin 1 (IL-1) is a potent mediator of inflammatory and immunologic phenomena. In addition, IL-1 may be intimately involved in the regulation of hemostasis, since interaction of IL-1 with endothelial cells has been reported to induce tissue factor activity. We demonstrate that perturbation of the endothelial cell induces augmented IL-1 release. Human umbilical vein endothelial cells pertu...

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