presentation 1. Lin Yang, Mei Sun, Hua Yang, Santo V. Nicosia, Jin Q. Cheng, Akt phosphorylates HtrA2/Omi and inhibits its serine protease and proapoptotic activities. 97 American Association for Cancer Research Annual Meeting, 2006. 2. Sungman Park, Santo V. Nicosia, Jin Q. Cheng. Regulation of the pro-apoptotic Gene 24p3 by phosphatidylinositol 3-kinase/Akt through FOXO3a. 97 American Associa...

Melanoma causes a majority of skin cancer related deaths even though it represents small fraction cancers. Remarkable advances in melanoma therapies are still unable to overcome therapy resistance. CXCL14, known chemokine for the chemotaxis and differentiation certain immune cells defense against bacterial infection, plays dual role It suppresses oral carcinomas, head neck cancers, lung whereas...

Here, we introduce an engineered, tunable genetic switch that couples repressor proteins and an RNAi target design to effectively turn any gene off. We used the switch to regulate the expression of EGFP in mouse and human cells and found that it offers >99% repression as well as the ability to tune gene expression. To demonstrate the system's modularity and level of gene silencing, we used the ...

• Molecular response to chemo-, radio- and radionuclide therapy was assessed in NENs. Cisplatin PRRT triggered DNA damage repair-related gene expression. Bortezomib inhibited repair related Combined resulted short-term pro-apoptotic effects vitro . Tumoral heterogeneity interfered with long-term sensitization assessment vivo Background: Well-differentiated gastroenteropancreatic neuroendocrine ...

In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of previously identified, caspase-generated proapoptotic protein fragments, defined as those that increase the probability of apoptosis. In contrast to activated caspases, which can be counteracted by inhibitor of apoptosis proteins, there is li...

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that mediates both NADH-oxidizing and caspase-independent apoptosis. Further, the proapoptotic activity of AIF is located in the C-terminus of AIF, although the precise minimum sequence responsible for apoptosis induction remains to be investigated. In the present study, we generated two truncated AIFs, AIFDelta1-480-FLAG, which is...

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral hepatitis and, more recently, from fatty liver diseases. Activation and proliferation of hepatic stellate cells (HSCs) represent a key aspect of fibrogenesis and are associated with progressive reduction of HSC apoptosis. Bcl-x, an antiapoptotic member of Bcl-2 gene family, plays a role in apoptosis regula...

BACKGROUND/AIMS Restenosis after a percutaneous coronary intervention (PCI) during treatment for coronary artery disease is closely related to smooth muscle cell (SMC) proliferation and migration. In this study, we investigated the effects of caffeic acid phenethyl ester (CAPE) and its underlying mechanism on human coronary SMCs (HCSMCs) after platelet-derived growth factor-BB (PDGF-BB) stimula...