Apoptosis is an important physiological process which enables organisms to remove unwanted or damaged cells. A mathematical model of the extrinsic pro-apoptotic signaling pathway has been introduced by Eissing et al. (2007) and a bistable behavior with a stable death state and a stable life state of the reaction system has been established. In this paper, we consider a spatial extension of the ...

Provided are a photographing pro?le learning apparatus and method of a digital imaging device for recording a personal life history. The photographing pro?le learning method learns a user’s photographing patterns by recommending at least one previous picture consistent With a user’s photographing tendencies, using a recommendation function and a user pro ?le based on a user feedback value and a...

The tripeptide pyro-Glu-His-Pro-NH2[thyrotropin-releasing hormone (TRH)] was isolated from the hypothalamus as a thyrotropin-releasing factor. It has a broad spectrum of central nervous system-mediated actions, including the stimulation of exocrine pancreatic secretion. TRH is also synthesized in the endocrine pancreas and found in the systemic circulation. Enzymatic degradation of TRH in vivo ...

In the late 1980s and early 1990s, pro-choice and anti-abortion activists battled over the sacred ground of motherhood. Signs wielded by protestors outside clinics often read, "Choose life-your mother did," while bumper-stickers on the pro-choice side struggled to fight fire with fire with the slogan, "Pro-Child, Pro-Family, Pro-Choice." Yet, in recent years, the mother-oriented pro-choice slog...

The viral proteases have proven to be the most selective and useful for removing the fusion tags in fusion protein expression systems. As a key enzyme in the viral life-cycle, the main protease (M(pro)) is most attractive for drug design targeting the SARS coronavirus (SARS-CoV), the etiological agent responsible for the outbreak of severe acute respiratory syndrome (SARS) in 2003. In this stud...

The exponential development of Patient-Reported Outcomes (PRO) measures in clinical research has led to the creation of the Patient-Reported Outcome and Quality of Life Instruments Database (PROQOLID) to facilitate the selection process of PRO measures in clinical research. The project was initiated by Mapi Research Trust in Lyon, France. Initially called QOLID (Quality of Life Instruments Data...

PHILOSOPHICAL CRITICISM serves a valuable end when it helps to clarify the truth. But clarity requires precision. Precision is especially necessary when one presents the arguments of those holding the view that is the focus of one’s criticisms. Where there is lack of precision, ambiguity and confusion may arise, which may in turn obscure the truth. For this reason I was deeply disturbed by the ...

BACKGROUND Randomised controlled trials (RCTs) in surgery can be challenging to conduct, and trials in the emergency surgical setting when patients have unplanned hospital admissions are particularly difficult. One area of challenge is capturing baseline patient-reported outcome (PRO) data. This study examined the feasibility and optimal methods for the collection of baseline and follow-up PRO ...

BACKGROUND Infertility has a negative impact on quality of life (QoL) and well-being of affected individuals and couples. A variety of patient-reported outcome (PRO) measures to assess infertility-related QoL are available; however, there is a concern regarding potential issues with their development methodology, validation and use. This review aimed to i) identify PRO measures used in infertil...