BACKGROUND Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types. We report the clinical presentation, natural history, and prognostic features of ATTRwt compared with cardiac-isolated AL amyloidosis and calculate the...

OBJECTIVES We sought to characterize natriuretic peptide levels in a cohort of rigorously characterized subjects with lone atrial fibrillation (AF). BACKGROUND Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are sensitive biomarkers of cardiac contractile dysfunction. Both peptides have been reported to be elevated in cohorts with AF, but previous studies have included su...

This study investigated the effects of three sport-specific high-intensity training units on cardiac biomarker alteration in elite athletes of dragon boating. Thirty six male (age 33 ± 9) and twenty nine female (age 31 ± 8) elite athletes, members of the German national team, were examined in their final training camp preparing for world championship. At two time points blood panels (pre-traini...

The aim of the present study was to evaluate whether B-type natriuretic peptides (BNPs) could serve as screening markers for the detection of preclinical vascular disease in the community. BNP and N-terminal-pro-BNP were analyzed in 1,000 subjects aged 70 years participating in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study and were related to different measur...

The objective of this systematic review was to assess whether pre-operative brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT pro-BNP) are independent predictors of adverse outcomes after cardiac surgery. MEDLINE, Embase and the Cochrane Controlled Trials Register databases were searched. Eligible studies included observational or randomized control trials measur...

Abbreviations: ACC/AHA, American College of Cardiology/American Heart Association; AF, atrial fibrillation; ANP, Atrial Natriuretic Peptide; AS, aortic stenosis; BNP, Brain Natriuretic Peptide; EF, ejection fraction; ESC, European Society of Cardiology; LA, left atrium; MR, mitral regurgitation; MS, mitral stenosis; MVA, mitral valve area; NT-Pro-BNP, N terminal-pro brain natriuretic peptide; P...

Turner syndrome (TS) is a chromosomal disorder that affects 1:2,000 females. It results from either the complete or partial loss of the X chromosome as well as other aberrations. Clinical features of TS include short stature, delayed puberty, and congenital cardiac malformations. TS children also have an increased prevalence of cardiometabolic risk factors, which predisposes them to complicatio...

Although B-type natriuretic peptide (BNP) has been used for the diagnosis of congestive heart failure in many clinical settings, its diagnostic role in critically ill patients remains uncertain. The body of literature suggests that BNP and N-terminal pro-BNP levels are not useful for the diagnosis of systolic or diastolic heart failure in the critically ill, including in patients with brain hem...

linkage essential for receptor binding. ANP and BNP are cardiac hormones mainly secreted from the atrium and the ventricle respectively, whereas CNP is of endothelial origin. ANP and BNP bind to the natriuretic peptide A-receptor (NPR-A) and mediate the biological actions of natriuresis, vasodilatation and renin inhibition. In contrast, CNP lacks renal actions but causes vasodilatation via bind...

N-terminal pro-brain natriuretic peptide, C-reactive protein, and uri-nary albumin levels as predictors of mortality and cardiovascular events in older adults. impact of plasma N-terminal pro-brain natriuretic pep-tide in severe chronic congestive heart failure: a substudy of the carvedilol prospective randomized cumulative survival (COPERNICUS) Studies of cardiopulmonary bypass in children: im...