Primary immunodeficiency disorders are a heterogeneous group of genetic disorders, with different modes of inheritance, consisting of more than 100 different types. We constructed the DNA banking of primary immunodeficiency disorders for the first time in Iran. The DNA of 31 immunodeficient patients and their families (total of 92 samples) were collected, as the first step for construction of D...

Increasing evidence supports that adults with low-risk penicillin allergy labels (PALs) can be delabeled direct oral amoxicillin challenge. Immunocompromised patients admitted acutely are at increased risk of infection and likely benefit disproportionately from delabeling. We investigated the efficacy, safety, effectiveness, outcomes immunodeficient PALs in intensive care setting. PAL to Medica...

Selective IgM immunodeficiency (SIgMID) is a heterogeneous disorder with no known genetic background and may occur as a primary or a secondary condition. Celiac disease has been reported in association with several humeral immunodeficiencies, including isolated severe selective IgA deficiency, panhypogammaglobulinemia, and isolated combined IgA and IgM deficiency. There are only few reported ca...

Antibody deficiencies constitute the majority of primary immunodeficiencies in adults. These patients have a well-established increased risk bacterial infections but there is lack knowledge regarding relative risks upon contracting COVID-19. In this monocentric study disease course COVID-19 1 patient with Good's syndrome and 13 common variable immunodeficiency (CVID) described. The severity ran...

Coeliac disease (CD) often coexists with other autoimmune and primary immunodeficiency diseases (PID), creating a problem in timely diagnosis and management. An unusual case of coeliac disease that was difficult to diagnose and manage because of its unusual clinical presentation. Initially diagnosed as celiac disease but showed poor response to standard therapy is reported. Frequent attacks of ...

Blastomycosis-like pyoderma (BLP) is a rare cutaneous disorder that results from an exaggerated response to bacterial infection, most commonly Staphylococcus aureus. There are variety of reported predisposing factors, including diabetes, obesity, leukemia, primary immunodeficiency, and immunomodulatory therapy. Clinical histopathological findings BLP can be quite disparate, often resulting in d...