introduction: ewing’s sarcoma is the second most common primary malignant tumor of bone found in children after osteosarcoma. it accounts for 4–9% of primary malignant bone tumors and it affects bones of the skull or face in only 1–4% of cases. hence it rarely affects the head and neck. subject and method: in this case report, we describe a case of primary ewing's sarcoma occurring in the tempo...

Cathepsin L is a kind of cystein proteases which are known to facilitate the invasion and metastasis of tumor cells by degrading the components of basement membrane and extracellular matrix. This study was undertaken to investigate the expression of cathepsin L by Northern blot analysis with radiolabeled cDNA specific for cathepsin L in six normal tissues, two osteosarcoma cell lines, MG-63 and...

BACKGROUND AND AIM: Intra-osseous pathologic lesions of the jaw bones have different radiological and clinicopathological features from benign to malignant lesions. The aim of this study was to determine the prevalence of jaw lesions in Isfahan, Iran, during 1992-2017. METHODS: In this descriptive-analytical study, all re...

Metastatic and primary bone tumors are malignant tumors affecting the skeleton. Although the prognosis of patients with these tumors has improved with the development of effective chemotherapy, the challenges of local recurrence, subsequent osteolysis, degradation of bone strength and unresectable tumors persist. Local control of these tumors is therefore a key strategy to address these limitat...

BACKGROUND Primary bone tumors remain a daunting challenge to orthopaedic surgeons. The challenge is heightened in developing countries due to limited diagnostic and therapeutic facilities and ignorance. The published literature on the subject is sparse in our environment. OBJECTIVE To describe the pattern of primary bone tumors seen in a tertiary hospital in Nigeria. METHODS This is a retr...

Giant cell tumor of the bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells. Giant-cell tumor of the bone accounts for 4-5% of primary bone tumors and ∼20% of benign bone tumors. Giant cell tumors of the hand are rare, accounting for only 2-4% of all giant cell tumors. Giant cell tumor (GCT) of the bones of the hand has some...

Chondroblastoma of the temporal bone is a rare condition. Chondroblastomas account for less than 1% of primary bone tumors, and those involving the temporal bone represent a tiny fraction of these tumors with most arising from the knee, rib, and pelvis. We present a case series of two patients who presented with chondroblastomas of the temporal bone over a period of 8 years to the St. Vincent's...

BACKGROUND The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progression to the aggressive change of bone tissue. METHODS Genome-wide array-based comparative genomic hybridization (array CGH) was used to investigate DCNAs of 14 samples from ...

PURPOSE To determine the diagnostic accuracy of image-guided percutaneous biopsy in 110 primary bone tumors of varying internal compositions. MATERIALS AND METHODS One hundred ten consecutive patients with primary bone tumors underwent biopsy with computed tomography (CT) or fluoroscopy. Ninety-one patients underwent surgical follow-up and 19 received medical treatment and underwent subsequen...

We investigated the effects of the matrix metalloproteinase 13 (MMP13)-selective inhibitor, 5-(4-{4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy}phenoxy)-5-(2-methoxyethyl) pyrimidine-2,4,6(1H,3H,5H)-trione (Cmpd-1), on the primary tumor growth and breast cancer-associated bone remodeling using xenograft and syngeneic mouse models. We used human breast cancer MDA-MB-231 cells inoculated into the...