نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

Journal: :Journal of Investigative Dermatology 2022

Acral melanoma is commonly diagnosed in people of color and has worse prognosis than cutaneous melanoma, even when controlling for tumor stage. Here, we seek to assess differences mutational profiles acral melanomas, which could potentially impact treatment outcomes. Mutational 1273 patients (118 1155 cutaneous) from the American Association Cancer Research Project Genomics Evidence Neoplasia I...

Journal: :International journal of oncology 2006
Ahmed Gassara Yosra Messai Catherine Gaudin Soraya Abouzahr Adbelali Jalil Maryam Diarra-Mehrpour Florence Faure Catherine Richon Marie-Françoise Avril Jos Even Salem Chouaib

Metastases are known to be more resistant to therapy than matching primary tumors, in particular they are less prone to apoptosis. In this study we investigated the functional interaction of a CTL clone (LT12) specific for a melanoma TA with the primary tumor (T1) versus its metastatic counterpart (G1). The CTL clone (LT12) was shown to lyse the primary T1 cells more efficiently in a classical ...

2017
Paolo Fagone Rosario Caltabiano Andrea Russo Gabriella Lupo Carmelina Daniela Anfuso Maria Sofia Basile Antonio Longo Ferdinando Nicoletti Rocco De Pasquale Massimo Libra Michele Reibaldi

Melanoma of the uveal tract accounts for approximately 5% of all melanomas and represents the most common primary intraocular malignancy. Despite improvements in diagnosis and more effective local therapies for primary cancer, the rate of metastatic death has not changed in the past forty years. In the present study, we made use of bioinformatics to analyze the data obtained from three public a...

Journal: :Actas dermo-sifiliograficas 2013
M González-de Arriba M T Bordel-Gómez J C Solera J Sánchez-Estella

Patients with cutaneous metastatic melanoma of unknown primary origin (stage IV M1a disease according to the American Joint Committee on Cancer melanoma staging system) have an estimated 5-year survival rate of between 5% and 17.9% and a median survival of 6 months. However, certain patients with stage IV M1a disease have much higher survival rates. The existence of this subpopulation has given...

Journal: :International journal of clinical and experimental pathology 2013
Predrag Jovanovic Marija Mihajlovic Jasmina Djordjevic-Jocic Slobodan Vlajkovic Sonja Cekic Vladisav Stefanovic

Ocular melanoma is the second most common type of melanoma after cutaneous and the most common primary intraocular malignant tumor in adults. Large majority of ocular melanomas originate from uvea, while conjunctival melanomas are far less frequent. Incidence of uveal melanoma has remained stable over last three decades. Diagnosis is in most cases established by clinical examination with great ...

Journal: :JAMA ophthalmology 2015
Gaia Barisione Marina Fabbi Alice Gino Paola Queirolo Laura Orgiano Laura Spano Virginia Picasso Ulrich Pfeffer Carlo Mosci Martine J Jager Silvano Ferrini Rosaria Gangemi

IMPORTANCE Conventional melanoma serum biomarkers (S100 and lactate dehydrogenase [LDH]) perform poorly in patients with uveal melanoma, and the search for new biomarkers is needed. A high expression of the oncoprotein c-Met in primary uveal melanoma is associated with metastatic progression, and c-Met is released as a soluble ectodomain through ADAM10- and ADAM17-mediated cleavage, suggesting ...

2013
Anand Rotte Madhuri Bhandaru Yabin Cheng Cecilia Sjoestroem Magdalena Martinka Gang Li

BACKGROUND Genomic instability due to UV radiation is one of the leading causes for melanoma. Histone acetyltransferase p300 plays an indispensible role in DNA repair and maintenance of genomic integrity. The present study was performed to analyze the correlation between p300 expression, melanoma progression and patient survival. METHODS Tissue microarray and immunohistochemical analysis was ...

Journal: :dental research journal 0
uzma iqbal belgaumi pushparaja shetty shilpa shirlal

malignant melanoma is a potentially aggressive tumor of melanocytic origin. primary oral malignant melanoma is a rare neoplasm, accounting for 0.5% of all oral malignancies. the present case occurred in a 60‑year‑old female patient, as a pedunculated growth involving the palate and alveolar ridge and histologically showing a desmoplastic differentiation. the article discusses the distinct clini...

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