Sensitivity to environmental shape in spatial navigation has been found, at both behavioural and neural levels, in virtually every species tested, starting early in development. Moreover, evidence that genetic deletions can cause selective deficits in such navigation behaviours suggests a genetic basis to navigation by environmental geometry. Nevertheless, the geometric computations underlying ...

Some temporal ontologies require a way of enforcing the temporal qualification of certain assertions—those about changing entities. In a knowledge representation language based on first–order logic, this is straightforwardly done by having a category of temporal regions and augmenting predicates with an additional argument place for the time at which a given predicate holds. Here, I address the...

p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears as a quite promising pharmacological approach and, effectively, several attempts have been made in...

In this letter, we make a prima facie case that there could be distinct advantages to exploiting a new class of finite flux equilibrium solutions of the Quantum Boltzmann equation in semiconductor lasers.

Interactions between 3 ́ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3 ́UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including ...

The management of identities on the Internet has evolved from the traditional approach (where each service provider stores and manages identities) to a federated identity management system (where the identity management is delegated to a set of identity providers). On the one hand, federated identity ensures usability and provides economic benefits to service providers. On the other hand, it po...

Small molecules with low molecular weight are of interest for drug development, as they are more likely to be absorbed. In cancer research, p53 is often mutated in many tumors, and many small molecules targeting mutant p53 have been tested. One of such low molecular weight compounds is APR246/PRIMA-1(MET) that was identified as a compound targeting and reactivating p53 mutants based on a cell-b...

The paper sets out a prima facie case for the claim that the classification of Sanskrit compounds in Pān. inian tradition can be retrieved from a very slight augmentation of the usual enriched context free rules.