Evaluated in this study were the effects of the two parameters, namely level of penetration enhancer and drug loading dose, on in vitro skin release of Caffeine and vitamin B5 and adhesion properties of drug in adhesive transdermal systems. In order to characterize in vitro drug release, a hydrodynamically Chien permeation system with rat abdominal skin was employed. Caffeine skin release rate ...

INTRODUCTION Tissue adhesives can be used as adjacent to sutures to drop or avoid bleeding in cardiovascular operations. OBJECTIVE To verify the efficiency of fibrin and cyanoacrylate adhesive to seal arterial sutures and if the adhesives penetrate through suture line to the inner of arteries. METHODS 20 abdominal aorta segments of pigs were divided into two groups according to the adhesive...

Based on the structural and experimental studies of more than 300 insect species from different lineages, we have developed and characterized a bioinspired polymer material with the ability of multiple glue-free bonding and debonding. The material surface is covered with a pattern of microstructures, which resembles the geometry of tenent hairs previously described from the feet of flies, beetl...

The debonding of Pressure Sensitive Adhesives (PSA) is a classical example of the difficult and unsolved issue of fracture in soft viscoelastic confined materials. The presence of a complex debonding region where the adhesive undergoes cavitation and the very large strain of a spontaneously formed fibrillar network has defied many modeling attempts over the past 70 years. We present here a nove...

PURPOSE To compare various pre-treatments serving as cleaning procedures of dentin on the bond strength of resin composite promoted by a universal adhesive system applied either in the absence or presence of simulated pulpal pressure. MATERIALS AND METHODS Prior to application of the adhesive system (Scotchbond Universal) and resin composite (Filtek Z250), ground dentin surfaces were given on...