The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like artemisinin particles was 30 to 1200 μm. The optimum micronization conditions ...

METHODS: Consecutive patients with medically controlled OAG and visually significant cataracts were treated with ECP and cataract extraction (study group) or cataract extraction alone (control group). The groups were matched in age and baseline intraocular pressure (IOP). The main outcome measures were the change in IOP and number of glaucoma medications. Secondary measures included visual acui...

A method for stably purifying a functional dye, phycocyanin from Spirulina platensis was developed by a hexane extraction process combined with high pressure. This was necessary because this dye is known to be very unstable during normal extraction processes. The purification yield of this method was estimated as 10.2%, whose value is 3%-5% higher than is the case from another conventional sep...

This work was aimed to extract and characterise the essential oils presented in the leaves of Moringa Oleifera using supercritical fluid extraction (SFE) and compare the results against those using the conventional Soxhlet extraction method. The oils extracted were analysed using GC-MS. The compounds were identified according to their retention indices and mass spectra (EI, 70eV). The effects o...

To improve the extraction of polycyclic aromatic hydrocarbons (PAHs) from sediment samples, we optimized the conditions of pressurized liquid extraction (PLE). The yields increased as the extraction temperature increased from 100 to 190 degrees C, but the effect of increasing pressure (from 15 to 20 MPa) was small. Parameters of 190 degrees C and 20 MPa, near the maximum of the equipment, gave ...

A supercritical fluid extraction (SFE) procedure for the analysis of temazepam from whole blood was developed. Quantitative recoveries were obtained by high-performance liquid chromatography using prazepam as an internal standard and carefully monitoring the extraction temperature and pressure. The results were found to compare well with those obtained by solid-phase extraction techniques, but ...

Extraction of heavy metals in membrane contactors was investigated theoretically in this study. Extraction of Cu2+ with a kerosene solution of di(2-ethylhexyl) phosphoric acid (D2EHPA) was studied. Simulations were performed using computational fluid dynamics of mass and momentum transfer in all subdomains of a circular membrane contactor. The membrane contactor consists of three sections: lume...

Preliminary communication The interest in high pressure technology during last decades increased intensively. Supercritical Fluid Extraction (SFE) is a process that is growing in importance as an alternative to conventional separation processes. SFE uses environmentally friendly CO2 as the extracting agent in the process because of its relatively low critical pressure (7,38 MPa), its low critic...

Remediation of heavy-metal-contaminated sediment is often hampered by the availability of heavy metals to the added chemical agents because the heavy metals are often shielded by the sediment matrix. Effective heavy-metal extraction technique becomes an important factor in enhancing the treatment efficiency. A novel extraction/washing technique utilizing chelating agent and elevated pressure in...

This work is focused on the chemical characterization of Maytenus ilicifolia extracts obtained from high-pressure CO2 extraction. The experiments were performed in a laboratoryscale unit, where the effect of particle size (35-200mesh), CO2 mass flow rate (1 to 3gmin), temperature (293 to 323K), pressure (100 to 250bar), and extraction time was investigated in terms of liquid yield and chemical ...