Advanced age is commonly associated with progressive cochlear pathology and central auditory deficits, collectively known as presbycusis. The present study examined central correlates of presbycusis by measuring response properties of primary auditory cortex (AI) layer V neurons in the Fischer Brown Norway rat model. Layer V neurons represent the major output of AI to other cortical and subcort...

Hearing loss is the most common sensory deficit in the elderly, and is becoming a severe social and health problem. Presbycusis is the result of aging which can lead to communication problems compromising the quality of life (QoL).Since the elderly population is increasing worldwide, presbycusis is showing a similar trend. This study intended to identify the impact of hearing loss in the social...

The interaction of noise with a variety of other agents and with some physical characteristics of the individual to produce noise-induced hearing loss is reviewed critically. The review is restricted, for the most part, to publications since 1970. Other agents interacting with steady-state noise that are reviewed here include: (1) ototoxic drugs (kanamycin, neomycin, ethacrynic acid, furosemide...

To study the underlying morphological changes of presbycusis, cochlea and cochlear nuclei from twenty three dogs, ranging in age from 3 days to 17 years, were examined histologically. Dogs used in this study were house dogs kept in an environment similar to that of humans. Four types of histological changes reported in human presbycusis, that is, loss of spiral ganglion cells, atrophy of the or...

OBJECTIVE To assess the audiometric profile and speech recognition characteristics in affected members of 2 families with DFNA6/14 harboring heterozygous mutations in the WFS1 gene that cause an autosomal dominant nonsyndromic sensorineural hearing impairment trait. DESIGN Family study. SETTING Tertiary referral center. Patients Thirteen patients from 2 recently identified Dutch families wi...

This study tested prospective models of anxiety and depression following a first time diagnosis of age-related hearing loss, also known as presbycusis, which is one of the most common and disabling health problems in the world. The predictor of interest was cognitive self-consciousness (CSC; Cartwright-Hatton & Wells (1997). Beliefs about worry and intrusions: The Meta-Cognitions Questionnaire ...

Peripheral deafness may be inherited or acquired, congenital or later-onset, and sensorineural or conductive. The most commonly observed forms are inherited congenital sensorineural, acquired later-onset sensorineural (ototoxicity, presbycusis) and acquired later-onset conductive (chronic otitis externa/media). In most dog and cat breeds inherited congenital sensorineural deafness results from ...

To investigate the changes of ribbon synapses (RS) number in cochlear hair cells in C57BL/6J mice with age. Basilar membranes within the cochlea of C57BL/6J mice aged 2, 6, 10 and 12 months were harvested (5 mice in each age group). The presynaptic and postsynaptic membranes were subject to double immunohistochemical staining and observed with a laser confocal microscope. The number of RS in ea...

Objectives Among older adults (OA), hearing loss is associated with an increased risk for falls. The aim of the present study was to experimentally investigate the cognitive compensation hypothesis, wherein decreased auditory and motor functioning are compensated by the recruitment of cognitive resources. Method Twenty-nine younger adults (YA), 26 OA, and 32 OA with age-related hearing loss (...

To evaluate the prevalence of central auditory disorder as a function of aging, we analyzed speech audiometric test results on 700 patients, 100 patients from each of seven half-decades beginning at age 50 years. In addition, we evaluated the extent to which prevalence estimates could be explained by the effect of hearing loss on measures of central auditory processing and the difference in pre...