urine sample) occurring after the 20th week of gestation. Edema is common in patients with preeclampsia but is not necessary for the diagnosis. Eclampsia is defined by seizures, usually in the setting of preeclampsia. Seizures are rare without underlying preeclampsia. Although preeclampsia develops most commonly after the 20th week of pregnancy, it may occur in the postpartum period, usually wi...

Several recent studies reveal the link between preeclampsia and future development of ESRD, CKD, and microalbuminuria (1–3). Preeclampsia is also associatedwith the subsequent development of cardiovascular disease (CVD) (4–6). Whether the pathogenesis of preeclampsia represents an unmasking of subclinical or unrecognized kidney disease, an independent insult to the kidneys leading to progressiv...

introduction the main aim of this study was to compare serum level of 25- hydroxyl vitamin d [25(oh) d] between women with preeclampsia and normal individuals and birth outcomes. material and methods this cross sectional study was conducted on 650 normal primigravida women in their first 24–28 weeks of pregnancy. after 3 months of follow-up, serum levels of 25(oh) d and calcium were measured in...

background: preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. it is suggested that cytokines such as tumor necrosis factor-alpha (tnf-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction. objective: the aim of this study was comparison o...

OBJECTIVE To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia. METHOD A systematic review and meta-analysis of randomized controlled trials were performed. Women who were randomized to low-dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included. The outcomes of interest were preterm preeclampsia (delivery <37 week...

Increased uric acid level is a key clinical feature of preeclampsia; higher levels correlate with significant maternal and fetal morbidity and mortality. The cause of hyperuricemia and its specific role in the pathogenesis of preeclampsia, however, remain unclear. Although uric acid has been shown to roughly parallel the severity of the maternal syndrome, it has not been useful in predicting th...

Introduction/Background: Preeclampsia is a pregnancy specific, multisystem disorder characterized by various biochemical abnormalities. Dyslipidemia and Hyperuricemia have been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations. Objectives: To evaluate Serum lipid profile and uric acid in preeclampsia subjects and to determine if there ...

The aim of this study was to investigate the expression and significance of the imprinted gene PEG10 (paternally expressed gene 10) in preeclampsia placental tissue. Quantitative real-time reverse transcriptase polymerase chain reaction and immunohistochemistry to evaluate mRNA and protein expression and distribution of PEG10 in placental tissues obtained from 22 preeclampsia patients (8 patien...

OBJECTIVE Length of sperm exposure has been proposed to influence the risk of preeclampsia. The main objective was to determine the relationship between extent of exposure to sperm, both before and during pregnancy, and the risk of preeclampsia. STUDY DESIGN A case-control design was used where women with preeclampsia (cases) were matched with two women without preeclampsia (controls) by age ...

Low-dose aspirin (LDA) is thought to prevent preeclampsia in high-risk pregnancy, but it is not universally used out of concern for its efficacy and safety. The authors meta-analyzed 29 randomized controlled trials (RCTs) to evaluate LDA for preventing preeclampsia and its complications. LDA can reduce the incidence of preeclampsia (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.57-0.87...