Aminopeptidases that generate antigenic peptides influence immunodominance and adaptive cytotoxic immune responses. The mechanisms that allow these enzymes to efficiently process a vast number of different long peptide substrates are poorly understood. In this work, we report the structure of insulin-regulated aminopeptidase, an enzyme that prepares antigenic epitopes for cross-presentation in ...

Purpose. To assess the effect of three-dimensional (3D) printed personalized moisture chamber spectacles (PMCS) on the periocular humidity. Methods. Facial computed tomography (CT) scanning was conducted on 10 normal subjects. PMCS was designed based on volume rendered CT images and produced using a 3D printer. Periocular humidity of PMCS and commercially available uniformed moisture chamber sp...

Small round-structured viruses (SRSV) are a group of RNA viruses that can cause gastroenteritis in persons of all ages. To determine the incidence of SRSV-associated gastroenteritis in The Netherlands and to study the genetic variability of outbreak strains, all outbreaks that were reported to the epidemiologists of the regional health services in 1996 were investigated using a standardized pro...

Fresh gas flows of 1-5 l./min containing oxygen concentrations of 25-50% in nitrous oxide were led into a semiclosed circle absorber circuit. The resulting inspired oxygen concentrations were measured under conditions of spontaneous respiration. The lower the fresh gas flow, the greater was the discrepancy between fresh gas and inspired oxygen concentration. No association between minute volume...

The Heston model is appealing as it possesses a stochastic volatility term as well as semiclosed formulas for pricing European options. Unfortunately, few simulation schemes for this model can handle the violation of the Feller Condition. An algorithm based on the exact scheme of Broadie and Kaya to simulate price paths under the Heston model is introduced. In order to increase the speed of the...