نتایج جستجو برای: pre clinical study
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A large, multidisciplinary symposium held at the National Institutes of Health in April and May 2009 brought together individuals from a wide range of scientific disciplines with the goal of promoting the nascent field of multimodality cardiovascular molecular imaging. This supplement to The Journal of Nuclear Medicine summarizes the presentations and discussions of that landmark symposium. The...
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Most current drug screening assays used to identify new drug candidates are 2D cell-based systems, even though such in vitro assays do not adequately re-create the in vivo complexity of 3D tissues. Inadequate representation of the human tissue environment during a preclinical test can result in inaccurate predictions of compound effects on overall tissue functionality. Screening for compound ef...
The management of the pain state is of great therapeutic relevance to virtually every medical specialty. Failure to manage its expression has deleterious consequence to the well-being of the organism. An understanding of the complex biology of the mechanisms underlying the processing of nociceptive information provides an important pathway towards development of novel and robust therapeutics. I...
yCanadian Arthritis Network, Canada zDepartment of Surgery, McGill University, Montreal, Quebec, Canada xCentocor Pharmaceuticals, Malvern, PA, USA k École Polytechnique, Montreal, Canada {Harvard University, Boston, MA, USA #Université de Montreal, Montreal, Canada yyConsumer Advisory Council, Canadian Arthritis Network, Canada zzUniversity of Calgary, Calgary, Canada xxMount Sinai Hospital, T...
Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. Most of the compounds that show remarkable anticancer effects in preclinical models actually fail when tested in clinical trials. We blame these failures on the complexity of the disease and on the limitations of the preclinical tools we require for our research. This manusc...
Background and objectives: Optimal surgical management of the neonate with imperforate anus (IA) depends on determining accurate location of muscle complex, pouch of rectum and urethral fistula. The aim of this study was to investigate a novel minimally invasive technique of anorectoplasty assisted by intraoperative sonography pull-through for repair of anorectal malformation and rectourinary f...
abstract lexical knowledge of complex english words is an important part of language skills and crucial for fluent language use (nation, 2001). the present study, thus, was an attempt to assess the role of morphological decomposition awareness as a vocabulary learning strategy on learners’ productive and receptive recall and recognition of complex english words. so 90 sophomores (female and ma...
language learning courseware has been receiving growing attention by english educators since its advent. a variety of softwares have been designed by software designers and resorted to by language educators to supplement language textbooks. this experimental study investigated how the application of computerized version of language textbooks and the reception of the entire course through comput...
Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...
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