Psychotic symptoms during the course of HIV infection constitute a known complication. New-onset psychosis, diagnosed usually by exclusion of other psychoses, is characterized by distinct constellation of symptoms and a varied clinical course, and has been linked to putative neurotransmitter pathology in cortical neurones. A case of new-onset psychosis in AIDS is discussed and it's theoretical ...

The paper intends an update to the theoretical and practical data on a seldom utilized technique but often considered as last therapeutically option, so the necessity to realize it correctly. In this second part are presented the indications of the technique for each type of pathology, together with the results and latest guideline indications.

Next-generation DNA sequencing devices have revolutionized cancer genomics by bringing whole genome resequencing of patients' tumours within practical and economic reach. We present an overview of the techniques involved and review early results from the resequencing of cancer genomes. The possible impacts of whole-genome and trancriptome resequencing in clinical cancer research and the practic...

Practical magnetic resonance imaging for use in investigative and preclinical toxicology studies is now feasible. Newly developed, self-containing imaging systems provide an efficient and cost-effective means to rapidly obtain in vivo and ex vivo magnetic resonance imaging images to improve how we perform toxicology and toxicologic pathology.

The title of this book would not have attracted my attention prior to being asked to review it. Neoplasia is covered in detail in existing GI pathology textbooks and there are also atlases of GI pathology. A quick glance at the contents, however, and I think the book should have been entitled ‘A Practical Guide (or Approach) to Neoplastic Gastrointestinal Pathology’. The introductory chapter co...

Most game-playing programs use minimax search: they build a game tree, heuristically evaluate the leaves, back up the heuristic values to the root and use them to select a move. Practice shows that the deeper such programs search, the better they play. However, mathematical models intended to explain this formally paradoxically showed that deeper search results in worse play [6,1]. This phenome...

What we know: Airway inflammation and remodelling of the airway wall play an important role in the pathophysiology of asthma in adults. There is a paucity of information regarding the pathology of asthma in early childhood. Postmortem and biopsy studies of children with asthma have consistently shown an increase in the size of mucous glands, but an increase in smooth muscle is seen only in some...