Aminoamide local anesthetics induce vasoconstriction in vivo and in vitro. The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contr...

BACKGROUND High-potency statins reduce cardiovascular events after acute coronary syndromes but remain underused in clinical practice. We examined predictors of nonuse of high-potency statins after acute coronary syndromes. METHODS AND RESULTS The Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial enrolled patients after an acute coronary syn...

High endogenous sexual hormone levels and use of medium potency estrogens are associated with a reduced risk of hip fracture in postmenopausal women. However, it is not clear if low potency estrogens confer the same benefits as the more widely used forms of menopausal hormone replacement. We examined the association between postmenopausal use of low potency estrogens, mainly estriol, and hip fr...

BACKGROUND The use of cannabis with higher Δ9-tetrahydrocannabinol content has been associated with greater risk, and earlier onset, of psychosis. However, the effect of cannabis potency on brain morphology has never been explored. Here, we investigated whether cannabis potency and pattern of use are associated with changes in corpus callosum (CC) microstructural organization, in patients with ...

BACKGROUND The potency of inactivated influenza vaccines is determined using a single radial immunodiffusion (SRID) assay. This assay is relatively easy to standardize, it is not technically demanding, and it is capable of measuring the potency of several vaccine strain subtypes in a multivalent vaccine. Nevertheless, alternative methods that retain the major advantages of the SRID, but with a ...

The cancer potency of MX ("mutagen X"; 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)furanone) was estimated from dose-response data of multiple MX-responding tumor sites observed among male and female rats exposed orally (Komulainen et al., 1997; 2000). These sites were liver, adrenal and thyroid in both sexes and mammary gland in the female. Other sites were associated with treatment, but were j...

BACKGROUND Elevated low-density lipoprotein cholesterol (LDL-C) is associated with an increased risk of coronary artery disease. Current guidelines recommend an LDL-C target of <70 mg/dL (<1.8 mmol/L) for acute coronary syndrome (ACS) patients, and the first-line treatment to lower lipids is statin therapy. Despite current guidelines and the efficacious lipid-lowering agents available, about ha...

The tuberculin for Mantoux-test is neither heated nor filtered after diluting, of course. Heating of a diluted tuberculin was once made half in fun. And as stated in section 3.1 and 6.1, a diluted tuberculin was sealed in ampuls, and heated by autoclaving for 20 minutes at 15 pounds pressure (120•Ž). After this precedure we saw a curious result: the potency was lost on the whole, of course, but...

This paper describes the use of an automatic classifier to model group potency levels within software development projects. A set of machine learning experiments that looked at different group characteristics and various collaboration measures extracted from a team’s communication activities were used to predict overall group potency levels. These textual communication exchanges were collected ...

We describe the attributes that span the space of attack tools, illustrate a class of nextgeneration attack tools and contrast it with contemporary worms, and outline a methodology that can be used to express the potency of the threat. In identifying what influences the potency of a threat we hope to identify underlying principles that govern the potency of a class of attack tools or a specific...