INTRODUCTION We hypothesized that mechanical ventilation per se increases abdominal edema and inflammation in sepsis and tested this in experimental endotoxemia. METHODS Thirty anesthetized piglets were allocated to one of five groups: healthy control pigs breathing spontaneously with continuous positive pressure of 5 cm H2O or mechanically ventilated with positive end-expiratory pressure of ...

In patients with acute respiratory distress syndrome, positive end-expiratory pressure is associated with alveolar recruitment and lung hyperinflation despite the administration of a low tidal volume. The best positive end-expiratory pressure should correspond to the best compromise between recruitment and distension, a condition that coincides with the best respiratory elastance.

Validation of AirPhysio Oscillating Positive Expiratory Pressure Device – Retail Short Paper Report Prepared by Professor Norman Morris, School of Allied Health Science and Menzies Health, Institute Griffith University Validation of AirPhysio Oscillating Positive Expiratory Pressure Device – Short Paper Report Prepared by Professor Norman Morris, School of Allied Health Science and Menzies Heal...

The function of the diaphragm and other respiratory muscles during exercise in chronic obstructive pulmonary disease (COPD) remains controversial and few data exist regarding respiratory muscle pressure generation in this situation. The inspiratory pressure/time products of the oesophageal and transdiaphragmatic pressure, and the expiratory gastric pressure/time product during exhaustive treadm...

The mechanisms generating intrinsic or auto-positive end-expiratory pressure (PEEP) during controlled mechanical ventilation in a relaxed patient also occur during spontaneous breathing or when the patient triggers the ventilator during an assisted mode [1, 2]. These include an increased time constant for passive exhalation of the respiratory system, a short expiratory time resulting from a rel...

RATIONALE Conventional positive-pressure ventilation delivers pressure to the airways; in contrast, negative pressure is delivered globally to the chest and abdomen. OBJECTIVES To test the hypothesis that ventilation with negative pressure results in better oxygenation and less injury than with positive pressure. METHODS Anesthetized, surfactant-depleted rabbits were ventilated for 2.5 hour...