Portal hypertension (PH) is a pathological condition characterized by persistent increase in pressure the portal vein pool (>10 mmHg) caused blood circulation blockage at various levels of system. PH accompanied varicose veins development (VV) esophagus and stomach. With progression main disease, severe complications occur (bleeding from stomach, liver failure). The combination pregnancy ser...

The interplay between mechanical stimuli and cellular mechanobiology orchestrates the physiology of tissues organs in a dynamic balance characterized by constant remodeling adaptative processes. Environmental properties can be interpreted as complex set information instructions that cells read continuously, to which they respond. In liver cirrhosis, chronic inflammation injury drive dysfunction...

Two dissimilar hemodynamic hypotheses, the "backward flow" theory and the "forward flow" theory, have been advanced to define splanchnic hemodynamics in portal hypertension. An animal model with portal hypertension and high-grade portal-systemic shunting, the portal vein-stenotic rat, was studied to determine whether a hemodynamic picture compatible with either theory would develop. Splanchnic ...