Using the lanthanide gadolinium (Gd(3+)) as a Ca(2+) replacing probe, we investigated the voltage dependence of pore blockage of Ca(V)1.2 channels. Gd(+3) reduces peak currents (tonic block) and accelerates decay of ionic current during depolarization (use-dependent block). Because diffusion of Gd(3+) at concentrations used (<1 microM) is much slower than activation of the channel, the tonic ef...

Hydrogen and some divalent cations block Na channels in a voltage-dependent manner (Woodhull 1973; Ulbricht and Wagner 1975; Mozhayeva et al. 1981, 1982a; Begenisich and Danko 1983). The potential-dependence of this blockage suggests that the binding site for blocking ions is situated in the pore at some fractional distance (<5) from the outside (Woodhull 1973). Alkaloid aconitine has been show...

Peripherally Inserted Central Catheter (PICC) blockage rate was audited over a two month period on the Trauma & Orthopaedics ward at our District General Hospital. A 70% (five out of seven) PICC blockage rate was observed. High blockage rates lead to potential treatment complications, delays in delivery of treatment, increase in costs, and reduction in patient satisfaction. The factors contribu...

This paper explores the influence of blockage and free-surface deformation on the hydrodynamic performance of a generic marine cross-flow turbine. Flows through a three-bladed turbine with solidity 0.125 are simulated at field-test blade Reynolds numbers, O(10(5)-10(6)), for three different cross-stream blockages: 12.5, 25 and 50 per cent. Two representations of the free-surface boundary are co...

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nanoporous anodic aluminum oxide (aao) has been used in many different fields of science and technology, due to its great structural characteristics. solar selective surface is an important application of this type porous material. this paper investigates the effect of nanoporous aao properties, including; film thickness, pore area percentage and pore diameter, on absorption spectra in the rang...

solute transport processes are affected by soil pore water velocity distribution. pore size distribution, which can be used to infer pore water velocity distribution, can be estimated from a soil water retention curve (n). in this study, a solute breakthrough curve was simulated using soil hydraulic parameters in four different soils. to evaluate the proposed model, predictions were compared to...