background: to compare a flexible, multi-dose gnrh antagonist protocol with a long gnrh .agonist protocol in poor respo materials and methods: a randomized clinical trial of 70 poor responder patients (35 patients in gnrh antagonist protocol and 35 patients in long gnrh agonist protocol) was performed at royan institute, tehran, iran. both groups were given a fixed dose of human menopausal gona...

In assisted reproductive techniques, the operator attempts to select morphologically best embryos to predict embryo viability. Development of polarized light microscope, which evaluates the oocytes' spindles according to birefringence of living cells, had been helpful in oocyte selection. The aim of this study is evaluating the relationship between meiotic spindles visualization and intracytopl...

Abstract Study question Does the transfer of a poor-quality blastocyst along with good-quality improve clinical outcomes compared to single in euploid-only cycles? Summary answer Transferring improved pregnancy rates but live birth were not significantly increased transfer. What is known already Single embryo transfers (SET) are often preferred when using euploid blastocysts good morphological ...

Background: Before human MII oocytes are vitrified they are usually denuded from their cumulus cells. In this study we wanted to investigate the effects of an intact corona radiata on the vitrification and fertilization of human oocytes. Materials and Methods: The study comprised two different parts. In Part 1, 36 MII stage oocytes, from 6 patients, were randomly assigned into a control group, ...

The developmental patterns of mosaic embryos have yet to be understood.1 aim this study is determine whether low and high level differ from euploid in morphologic characteristics. included ovarian stimulation cycles a single academic institution with preimplantation genetic testing for aneuploidy (PGT-A) January 2020-March 2021. Trophectoderm (TE) biopsies were analyzed using modified FAST-SeqS...

CONTEXT Mutations of the fragile X mental retardation 1 (FMR1) gene are associated with distinct ovarian aging patterns. OBJECTIVE To confirm in human in vitro fertilization (IVF) that FMR1 affects outcomes, and to determine whether this reflects differences in ovarian aging between FMR1 mutations, egg/embryo quality or an effect on implantation. DESIGN, SETTING, PATIENTS IVF outcomes were ...

A retrospective analysis of results from 114 initiated in-vitro fertilization cycles utilizing pronuclear embryo transfer is presented. Patients were unselected for age or infertility criteria, constituted a continuous series and were grouped according to response to stimulation (Group 1, ideal; Group 2, suboptimal) or ovarian reserve (Group 3, poor). At 16-18 h post-insemination, embryos were ...

Human embryos donated for embryonic stem cell (ESC) derivation have often been cryopreserved for 5-10 years. As a consequence, many of these embryos have been cultured in media now known to affect embryo viability and the number of ESC progenitor epiblast cells. Historically, these conditions supported only low levels of blastocyst development necessitating their transfer or cryopreservation at...