BACKGROUND Poor ovarian response phenomenon has been observed in some of the in vitro fertilization-embryo transfer patients. Some investigations found that follicle stimulating hormone receptor ( FSHR ) gene plays a role in the process, but no direct evidence shows the correlation between genotypes of FSHR and ovarian response. OBJECTIVE Exploring the molecular mechanism behind the mutation ...

BACKGROUND The use of progestin (P) during ovarian stimulation is effective in blocking the luteinizing hormone (LH) surge in women with normal ovarian reserve, however, its effects have not been determined in poor responders. This study aimed to explore the follicular dynamics in P-primed minimal stimulation in poor responders. METHODS A total of 204 infertile women with diminished ovarian r...

may have been influenced by the presence of M540 bodies. M540 bodies are indeed mysterious structures. They stain positively with merocyanine, a fluorescent membrane probe normally associated with the measurement of membrane potential and disorder, and also generate signals in the TUNEL assay, even though these structures do not stain with DNA sensitive fluorochromes such as YOPRO-1 (Marchiani ...

Background: Assessment of AMH cut-off levels in serum and in follicle fluid (FF) for patients with (group 2, n=34) and without (group1, n= 96) endocrinological risk factors, such as ovarian hyperstimulation syndrome (OHSS) and polycystic ovary syndrome (PCOS), is clinically useful in optimising the treatment protocol. Materials and Methods: AMH was analysed in serum and FF of 130 infertile pati...

Background Evaluation of anti-mullerian hormone (AMH) cut-off levels in assisted reproductive technology (ART) as predictive factor for individualization of stimulation protocols and to avoid ovarian hyperstimulation syndrome (OHSS). MaterialsAndMethods In a retrospective study, 177 infertile patients were assessed for AMH in serum and follicular fluid (FF) on the day of follicular puncture (FP...

BACKGROUND Management of poor-responding patients is still major challenge in assisted reproductive techniques (ART). Delayed-start GnRH antagonist protocol is recommended to these patients, but little is known in this regards. OBJECTIVE The goal of this study was assessment of delayed-start GnRH antagonist protocol in poor responders, and in vitro fertilization (IVF) outcomes. MATERIALS AN...

Women with diminished ovarian reserve often respond poorly to controlled ovarian stimulation resulting in retrieval of fewer oocytes and reduced pregnancy rates. It has been proposed that pre-IVF Dehydroepiandrosterone (DHEA) adjuvant therapy may improve ovarian response and pregnancy rates in women with diminished ovarian reserve. This meta-analysis aims to investigate efficacy of DHEA as an a...