Solid dispersions of ibuprofen (IBU) were prepared by solvent evaporation method using polyvinyl pyrrolidone (PVP) and/or sodium lauryl sulphate (SLS). Physicochemical properties of the various solid dispersion systems were determined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis. The results from dissolution studies indicated that ternary solid dispersion syst...

Pd doped WO3 fibers were synthesized by electro-spinning. The sol gel method was employed to prepare peroxopolytungstic acid (P-PTA). Palladium chloride and Polyvinyl pyrrolidone (PVP) was dissolved in the sol Pd:WO3 = 10% molar ratio. The prepared sol was loaded into a syringe connected to a high voltage of 18.3 kV and electrospun fibers were collected on the alumina substrates. Scanning elect...

The influence of water chemistry on characterised polyvinyl pyrrolidone- (PVP-) coated silver nanoparticles (81 nm) was investigated. NaCl solution series of 100-800 mg L(-1) lead to initial and temporal increase in nanoparticles size, but agglomeration was limited. pH variation (5-8) had only minor influence on the hydrodynamic particle size. Acute toxicity of nanosivler to zebrafish (Danio re...

The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surfacet opography of the patches was examined by scanning electron microscopy (S...

Buccoadhesive buccal delivery systems for isosorbide dinitrate in the form of unidirectional buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like Carbopol 934P and polyvinyl pyrrolidone by using two different plasticizers propylene glycol and diethyl phthalate. Unidirectional re...

Colloidal solutions of silver nanoparticles (AgNPs) were synthesized by gamma Co-60 irradiation using different stabilizers, namely polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), alginate, and sericin. The particle size measured from TEM images was 4.3, 6.1, 7.6, and 10.2 nm for AgNPs/PVP, AgNPs/PVA, AgNPs/alginate, and AgNPs/sericin, respectively. The influence of different stabilizers ...

Nutritive values of green and black tea by-products and anti-nutritive activity of their tannins were evaluated in an in vitro rumen fermentation using various molecular weights of polyethylene glycols (PEG), polyvinyl pyrrolidone (PVP) and polyvinyl polypyrrolidone as tannin-binding agents. Significant improvement in gas production by addition of PEG4000, 6000 and 20000 and PVP was observed on...

1. Abstract: The objective of this work was to develop suitable film formulations of ketorolac tromethamine (KT) for transdermal use and to investigate the effect of film composition and permeation enhancers on the in-vitro release and skin permeation of the drug. Polyvinyl alcohol (PVA), sodium carboxymethylcellulose (NaCMC), and chitosan were used as film-forming polymers. The adhesive hydrop...

Incubation of 2-[14C]pyrrolidone with sliced rat liver and analysis of the incubation medium by silica gel chromatography revealed that 2-[14C]pyrrolidone is metabolized to an unknown. It was previously shown by Lundgren and Hankins ((Lundgren, D.W, and Hankins, J. (1978) J. Biol. Chem. 253, 7130-7133) that slices of rat liver readily synthesized 2-pyrrolidone from putrescine. The unknown metab...