Improving the solubility of polysubstituted 1,4-naphthoquinone derivatives was achieved by introducing nitrogen in two different positions of the naphthoquinone core, at C-5 and at C-8 of menadione through a two-step, straightforward synthesis based on the regioselective hetero-Diels-Alder reaction. The antimalarial and the antischistosomal activities of these polysubstituted aza-1,4-naphthoqui...

The mol-ecule of the title compound, C(12)H(14)N(4), lies about a crystallographic inversion centre. The five- and six-membered rings are twisted from each other, forming a dihedral angle of 18.06 (7)°. In the crystal structure, neighbouring mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds into one-dimensional infinite chains forming 18-membered rings with R(2) (2)(18) motifs. The ...

The chemical name of the title compound in the paper by Kia, Fun & Kargar [Acta Cryst. (2009), E64, o2406] is corrected.[This corrects the article DOI: 10.1107/S1600536809023320.].

Inverse-electron-demand Diels–Alder (IEDDA) reactions of electron-poor 2-pyrones as electrophilic dienes have been extensively studied in the past fifty years. These provide an efficient access to bridged bicyclic lactones and their derivatives, such densely functionalized 1,3-cyclohexadienes after CO2 extrusion polysubstituted aromatic compounds through elimination. This reaction has used for ...

Extensive expositions of the isomer enumeration methods can be found in the review Dipers of Rouvray [1, 2]. The problem of enumerating isomers essentially reduces to finding what is known as the cycle index of a permutation group [3] and then obtaining a generating function for isomers using a theorem of Polya [3]. Read [4] stated that a method is yet to be developed for the enumeration of ste...

n-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-[14c-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14c] as a keysynthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14c]-cyanide in thepresence of tetrakis (triphenylphosphine) palladium.