Adrenal hemangioma is an uncommon benign vascular tumor that is often discovered incidentally. It has never been reported in association with familial adenomatous polyposis. We report a case of a 60-year old man with a history of familial adenomatous polyposis, in whom a huge retroperitoneal cyst of 18x17 cm was discovered during routine radiologic evaluation. Because of the impossibility of ru...

Lynch syndrome and familial adenomatous polyposis (FAP) have long been identifi ed as hereditary predisposition syndromes to colorectal cancer (CRC), most easily recognized on the basis of their autosomal dominant inheritance, young age of onset of CRC and other associated malignancies, and, in the case of FAP, the presence of adenomatous polyposis. However, in 2002 the fi rst report of a novel...

Intestinal polyposis syndromes, such as familial adenomatous polyposis (FAP) and Cowden's syndrome, are often associated with extraintestinal manifestations, and while many of these manifestations are benign, malignant extraintestinal manifestations, such as differentiated thyroid cancers, do occur. Although differentiated thyroid cancers (ie, papillary and follicular thyroid carcinomas) are as...

Cap polyposis is a rare intestinal disorder. Characteristic endoscopic findings are multiple inflammatory polypoid lesions covered by caps of fibrous purulent exudate. Although a specific treatment has not been established, some studies have suggested that eradication therapy for Helicobacter pylori (H. pylori) is effective. We report a case of a 20-year-old man with cap polyposis presenting wi...

MYH-associated polyposis is an autosomal recessive disorder recognized in the last 10 years. Here we describe a case with a never reported mutation in MYH gene resulting in MYH-associated polyposis. Porpiglia SA, Hall JM, Meyer EJ, Forman DA, Rybak C, Fleider FD, Cooper SH and Farma MJ* Fox Chase Cancer Center, Philadelphia, USA Farma MJ, et al. Clinics in Surgery Colon and Rectal Surgery Remed...

Introduction: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a relatively common disease with serious impacts on patient quality of life. Recurrence of polyps after functional endoscopic sinus surgery (FESS) is a dilemma. Vitamin D3 (VD3) is known to inhibit the proliferation of nasal polyp-derived fibroblasts. The present study aimed to investigate the effects of oral VD3 on the...

Base excision repair (BER) protects against damage to DNA from reactive oxygen species, methylation, deamination, hydroxylation and other by-products of cellular metabolism. Until last year, inherited deficiencies in the BER pathway had not been causally linked with any human genetic disorder. An apparent explanation was functional redundancy between proteins in this and other pathways. However...

Background Familial adenomatous polyposis (FAP) is a rare hereditary colorectal cancer syndrome estimated to account for about 1% of colorectal cancers. While there is variation in the FAP phenotype amongst individuals and families with mutations, it is characterized by a striking phenotype of colonic polyposis and other distinctive features such as desmoids and gastric fundic gland polyps. It ...

The case is reported of a 42 year old woman who presented with the characteristic clinical, sigmoidoscopic, and histological features of cap polyposis occurring in the postoperative course of pelvic surgery. Pathogenesis of cap polyposis is unknown. In this patient, abnormal colonic motility was not a likely aetiological factor as suggested in previous cases. Despite some arguments favouring an...

We describe a patient who was diagnosed with multiple tubulleuvillous adenomas focus of high-grade tubular dysplasia all over the colonic mucosa, discovered during colonoscopy performed an episode melena. Genetic testing has identified germline truncating mutation at codon (5q22.2) adenomatous polyposis (APC) gene. This is localized in alternately spliced region exon 12, which associated attenu...