نتایج جستجو برای: polymorphism il6

تعداد نتایج: 109750  

2013
Henrik Nausch Jana Huckauf Roswitha Koslowski Udo Meyer Inge Broer Heike Mikschofsky

In this study, we compared basic expression approaches for the efficient expression of bioactive recombinant human interleukin-6 (IL6), as an example for a difficult-to-express protein. We tested these approaches in a laboratory scale in order to pioneer the commercial production of this protein in Escherichia coli (E. coli). Among the various strategies, which were tested under Research and De...

Journal: :Blood 2007
Athena Chalaris Björn Rabe Krzysztof Paliga Hans Lange Tamas Laskay Ceri A Fielding Simon A Jones Stefan Rose-John Jürgen Scheller

Interleukin 6 (IL6) trans-signaling has emerged as a prominent regulator of immune responses during both innate and acquired immunity. Regulation of IL6 trans-signaling is reliant upon the release of soluble IL6 receptor (sIL6R), which binds IL6 to create an agonistic IL6/sIL6R complex capable of activating cell types that would not normally respond to IL6 itself. Here we show that intrinsic an...

Journal: :Journal of tropical pediatrics 2000
M O Magudumana D E Ballot P A Cooper J Trusler B J Cory E Viljoen A C Carter

The objective of the present study was to evaluate serial interleukin 6 (IL6) levels in the early diagnosis of neonatal sepsis. Subjects included 255 neonates from the Neonatal Unit of Johannesburg Hospital evaluated for suspected sepsis between February and May 1998. All infants had IL6, full blood count (FBC), C reactive protein (CRP) and blood cultures done at presentation. CRP and IL6 were ...

Journal: :The Journal of clinical investigation 2000
J Dai D Lin J Zhang P Habib P Smith J Murtha Z Fu Z Yao Y Qi E T Keller

To investigate the role of IL-6 in alcohol-mediated osteoporosis, we measured a variety of bone remodeling parameters in wild-type (il6(+/+)) or IL-6 gene knockout (il6(-/-)) mice that were fed either control or ethanol liquid diets for 4 months. In the il6(+/+) mice, ethanol ingestion decreased bone mineral density, as determined by dual-energy densitometry; decreased cancellous bone volume an...

Journal: :The Journal of Experimental Medicine 2007
Masahiro Yamamoto Satoshi Uematsu Toru Okamoto Yoshiharu Matsuura Shintaro Sato Himanshu Kumar Takashi Satoh Tatsuya Saitoh Kiyoshi Takeda Ken J. Ishii Osamu Takeuchi Taro Kawai Shizuo Akira

Toll-like receptors (TLRs) recognize a variety of microbial components and mediate downstream signal transduction pathways that culminate in the activation of nuclear factor kappaB (NF-kappaB) and mitogen-activated protein (MAP) kinases. Trib1 is reportedly involved in the regulation of NF-kappaB and MAP kinases, as well as gene expression in vitro. To clarify the physiological function of Trib...

Journal: :European journal of endocrinology 2008
Milos Zarković Svetlana Ignjatović Marijana Dajak Jasmina Cirić Biljana Beleslin Slavica Savić Mirjana Stojković Petar Bulat Bozo Trbojević

OBJECTIVE Interleukin 6 (IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. DESIGN AND METH...

Journal: :Cancer research 2015
Carla S Milagre Ganga Gopinathan Gemma Everitt Richard G Thompson Hagen Kulbe Haihong Zhong Robert E Hollingsworth Richard Grose David D L Bowtell Daniel Hochhauser Frances R Balkwill

Excess production of the proinflammatory IL6 has both local and systemic tumor-promoting activity in many cancers, including ovarian cancer. However, treatment of advanced ovarian cancer patients with a neutralizing IL6 antibody yielded little efficacy in a previous phase II clinical trial. Here, we report results that may explain this outcome, based on the finding that neutralizing antibodies ...

Journal: :American journal of respiratory cell and molecular biology 2005
Kristen Page Valerie S Hughes Kelli K Odoms Katherine E Dunsmore Marc B Hershenson

German cockroach extract synergistically regulates tumor necrosis factor-alpha (TNF-alpha)-induced interleukin (IL)-8 expression in human airway epithelial cells. The IL-8 promoter contains nuclear factor (NF)-kappaB, activating protein (AP)-1, and NF for IL-6 (NF-IL6) transcription factor binding regions. Because cockroach extract activates extracellular regulated kinase (ERK), a known activat...

Journal: :Biochimica Et Biophysica Acta - Molecular And Cell Biology Of Lipids 2021

Inflammation is a constant in Non-Alcoholic Fatty Liver Disease (NAFLD), although their relationship unclear. In transgenic zebrafish system with chronic systemic overexpression of human IL6 (IL6-OE) we show that inflammation can cause intra-hepatic accumulation triglycerides. Transcriptomics and proteomics analysis the IL6-OE liver revealed deregulation glycolysis/gluconeogenesis pathway, espe...

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