Background: Tuberculosis (TB) is one of the most significant health-care problems worldwide. The host’s genetics play an important role in the development of TB in humans. The disease progresses through several stages, each of which can be under the control of different genes. The precise genes influencing the different stages of the disease are not yet identified. The aim of the current study ...

Background & Aims: Vesicoureteral Reflux (VUR) is a congenital defect of the urinary tract which has been reported in approximately 1% of children. Several immunological and genetic factors are listed as major causes of this problem. The C825T polymorphism of the GNB3 gene is among the genetic factors that may be involved in the development or progression of the disease. Participatory role o...

Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism (nucleotide variations) w...

Clopidogrel is a widely-used antiplatelet drug. It important for the treatment and prevention of coronary heart disease. can effectively reduce platelet activity therefore stent thrombosis. However, some patients still have ischemic events despite taking clopidogrel due to alteration in metabolism attributable various genetic non-genetic factors. This review aims summarise mechanisms causes res...

tomato as a highly nutritious vegetable crop is widely grown in the world. hybrid seed is preferably used for tomato production. identification of superior hybrid combination is one of the most important steps in the hybrid breeding programs. breeding of high yielding hybrids is expensive and involves testing large numbers of hybrid combinations in multi-environment trials. successful predictio...

breeding for resistance is one of the main approaches to control diseases. in this approach, there is a necessary for existence a sufficient genetic variability of resistance genes. accordingly, assessing the genetic variability in the available germplasm is needed to manage genetic resources. molecular markers are effective tools to investigate genetic diversity for resistance to pathogens. nb...

Iran is a part of the secondary centre of origin of melons, and therefore, there is a wealth of genetic variation of these species in this country. The Amplified Fragment Length Polymorphism (AFLP) marker was applied to investigate the genetic variations among five major Iranian melon cultigens (Cucumis melo) and ‘Ananasi’ as a general well-known cultivar. Ten primer pairs were used on 90 indiv...

Genetic study of pistachio, especially male genotypes due to the effects of pollen on nut quality and quantity and next generation characterizations, help to improve its management and breeding programs. We studied the genetic diversity among 20 male and 36 female pistachio genotypes using ISSR marker. In total 178 DNA frgments were proliferated using 12 primers that 169 fragments were polymorp...