نتایج جستجو برای: polycythemia vera
تعداد نتایج: 10734 فیلتر نتایج به سال:
The role of erythropoietin (EP) in polycythemia vera (PV) is controversial, with some experiments suggesting that erythroid progenitors in PV are exquisitely sensitive to EP and EP dependent, and others suggesting that PV progenitors are EP independent. We have examined the characteristics of the EP receptor (EP-R) on erythroid colony-forming cells (ECFC) from patients with PV. In contrast to n...
A case of primary polycythaemia presenting with severe chorea is reported and compared with previous cases. The aetiological factors of the chorea are discussed and the importance of early diagnosis stressed.
In the September 15, 2003, issue of Blood,1 Oehler et al describe imatinib mesylate inhibition of the autonomous in vitro proliferation of peripheral blood– and bone marrow–derived polycythemia vera (PV) erythroid burst-forming units (BFU-Es). While their results superficially correlate with the previously published in vivo clinical observations of Silver,2 the conclusions of Oehler et al are a...
By B. MODAN, B. PADEH, H. KALLNER, E. Axsr IN, D. MEYTES, P. CZERNIAK, B. RAMOT, J. PINKHAS AND M. MODAN T HE RELATIVELY HICH RISK of developing leukemia in the course of polycythemia vera ( PV ) , and the presence of both specific and nonspecific chromosomal aberrations in patients with myeloprohferative disorders,25 led us to undertake a prospective follow-up study of patients with PV. In thi...
Background and Aim: The JAK2 is an acquired mutation that is observed in majority of patients with classical Philadelphia-negative Myeloproliferative neoplasms that include polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). This acquired mutation is characterized by a G to T transversion at nucleotide 1849 in exon 12 of the JAK2 gene, leading to a substitution ...
Between 1971 and 1981, 74 patients with polycythemia vera were treated with pipobroman using a high-dose induction, low-dose maintenance regimen. Complete remission was achieved in 51 of 54 previously untreated patients (94.4%) and in 17 of 20 patients (85%) previously treated wih radioactive phosphorus (32 p) and busulfan. The earliest modifications were noted on day 16, and on the average, bl...
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