Narrow temperature range distillates from biologically active solvent refined coal-l and -II heavy-end coal liquids were fraction ated according to chemical class and assayed for initiation of skin carcinogenesis in CD-1 mice. In addition, instrumental chem ical analyses were performed on the distillates and their chemical fractions. Results showed that initiation activity in these complex fuel...

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity. Ten aza-polycyclic aromatic hydrocarbons (aza-PAHs), consisting of nitrogen substituted naphthalenes, phenanthrenes, chrysenes, and benzo[a]pyrenes (BaPs), were subjected to analysis of their structure-acti...

The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the...

Alkylated polycyclic aromatic hydrocarbons (APAHs) are abundant in petroleum, but data regarding their toxicological properties are limited. A survey of all monomethylated phenanthrene structures revealed that they were 2 times to 5 times more potent than phenanthrene for activation of human aryl hydrocarbon receptor in a yeast bioassay. Phenanthrenes with equatorial methyl groups had the great...

Polycyclic aromatic hydrocarbon (PAH) degrading Sphingomonas sp. strain KS14 was isolated from soil. Strain KS14 was able to utilize phenanthrene and naphthalene as sole source of carbon and energy, and mineralize phenanthrene to carbon dioxide. Strain KS14 cometabolically degraded pyrene using phenanthrene as secondary growth substrate. A large degradative plasmid (>500 kb) was detected from t...

Benzene and pyrene can be synthetically linked to [o-COSAN]− keeping their aromaticity. In contrast, naphthalene anthracene are extruded in the same reaction. We have proven that extrusion is only favorable if number of Clar's π-sextets remains constant. Thus, Clar has answer whether an attached polycyclic aromatic hydrocarbon or not.

Oil Shale One alternative source of energy is the extraction of the organic components of oil shale to yield oil and gas. shale deposits occur throughout the United States.. The release of the energy yielding organic fraction from oil shale has been brought about by retorting the oil shale at temperatures above 500° C and distillating the organic material. in the form of spent oil shale ash. A ...