poliomyelitis (polio) is a highly infectious viral disease, which mainly affects young children. the virus is transmitted by person-to-person spread mainly through the faecal-oral route or, less frequently, by a common vehicle (e.g. contaminated water or food) and multiplies in the intestine, from where it can invade the nervous system and can cause paralysis. initial symptoms of polio include ...

Poliomyelitis (polio) is a highly infectious viral disease, which mainly affects young children. The virus is transmitted by person-to-person spread mainly through the faecal-oral route or, less frequently, by a common vehicle (e.g. contaminated water or food) and multiplies in the intestine, from where it can invade the nervous system and can cause paralysis. Initial symptoms of polio include ...

While enteroviruses have been the most commonly identified cause of aseptic meningitis in the United States, the role of the emerging, neurotropic West Nile virus (WNV) is not clear. In summer 2001, an aseptic meningitis epidemic occurring in an area of a WNV epizootic in Baltimore, Maryland, was investigated to determine the relative contributions of WNV and enteroviruses. A total of 113 asept...

The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is available against enteroviruses except for poliovirus. Enteroviruses subvert the autophagic machinery...

Pakistan is one of the two endemic countries for polio, reporting co-circulation WPV1 and cVDPV2. classified by International Health Regulations (IHR) as a state infected with Wild Poliovirus type 1 (WPV1) circulating Vaccine derived poliovirus 2 (cVDPV2) potential risk international spread. We describe an ongoing outbreak in North Waziristan district southern Khyber Pakhtunkhwa (KP) province l...

Hand, foot, and mouth disease (HFMD) is an infectious disease caused by human enterovirus 71 (EV71), coxsackievirus A16 (CVA16) and other enteroviruses. It is of interest that other enteroviruses associated with HFMD in Jinan have been rarely reported. The aim of the present study is to detect and characterize the circulating serotypes of non-EV71 and non-CVA16 enteroviruses associated with HFM...

Even as the physical causes and treatments for post-polio sequelae (PPS) are being identified, psychological symptoms--chronic stress, anxiety, depression, and compulsive, Type A behavior--are becoming evident in polio survivors. Importantly, these symptoms are not only causing marked distress but are preventing patients from making the lifestyle changes necessary to treat their PPS. Neither cl...

Nonpoliovirus enteroviruses cause a variety of diseases that are common in young children and adults. The "gold standard" for laboratory diagnosis of enteroviruses is cell culture isolation, followed by serotype identification by neutralization assay. These procedures are time-consuming and expensive. Rapid serotype identification of enteroviruses is important in differentiating nonpoliovirus e...

To the Editor: In July 2007, an Australian traveler imported polio from Pakistan to Australia (1). He was a 22-year-old man who had immigrated to Australia and had traveled to his country of origin (Pakistan) to visit friends and relatives. Pakistan is one of 4 countries (Afghanistan, India, Nigeria, Pakistan) where polio is still endemic. A diagnosis of polio was made shortly after his return ...

As the world takes rapid strides in the eradication of polio, the trivalent inactivated polio vaccine (IPV) would be the only polio vaccine available in the near future. Since the maintenance of herd immunity is important for sustaining polio eradication, this vaccine would need to be used in the early childhood immunization schedule for many years to come [1]. WHO’s Strategic Advisory Group of...