BACKGROUND Monitoring of HIV viral load in patients on combination antiretroviral therapy (ART) is not generally available in resource-limited settings. We examined the cost-effectiveness of qualitative point-of-care viral load tests (POC-VL) in sub-Saharan Africa. DESIGN Mathematical model based on longitudinal data from the Gugulethu and Khayelitsha township ART programmes in Cape Town, Sou...

The process of translating a basic scientific discovery into a novel therapeutic that improves public health is immensely gratifying. A particularly exciting time in the translation process is the early clinical testing to assess—for the first time—whether a novel molecule is efficacious in humans. This “proof-of-concept” (POC) stage of translation has a high risk of failure and must be careful...

OBJECTIVE To assess the utility of a point-of-care (POC) capillary blood glucose measurement as compared with routine clinical parameters in predicting undiagnosed diabetes in a low-resource rural India setting. RESEARCH DESIGN AND METHODS Nine hundred and ninety-four participants aged >30 years and stratified by age and sex were randomly selected from 20 villages in India. A clinical questio...

INTRODUCTION Early initiation of antiretroviral therapy (ART) in eligible pregnant women is a key intervention for prevention of mother-to-child transmission (PMTCT) of HIV. However, in many settings in sub-Saharan Africa where ART-eligibility is determined by CD4 cell counts, limited access to laboratories presents a significant barrier to rapid ART initiation. Point-of-care (POC) CD4 cell cou...

INTRODUCTION Inflammatory responses following tissue injury are essential for proper tissue regeneration. However, dysfunctional or repetitive inflammatory tissue assaults can lead to poor tissue regeneration and ultimate tissue failure via fibrosis. Previous attempts at urinary bladder tissue regeneration utilizing polymeric and biologic scaffolding materials tended to elicit these responses l...

Background: Platinum-based pre-operative chemotherapy (POC) for muscle-invasive bladder cancer (MIBC) increases the complete pathological response rate at cystectomy and improves overall survival. However, 60% of MIBC patients still has muscle-invasive disease at cystectomy despite POC. Therefore, accurate prediction of response to POC is an important clinical need. We hypothesized that an elev...

Title of Document:TRANSPORT, SOURCES, AND QUALITY OFSESTON IN A PIEDMONT HEADWATERSTREAMDavid Charles Richardson, Doctor of Philosophy2008Directed By:Dr. Margaret Palmer, Marine, Estuarine andEnvironmental Science, Chesapeake BiologicalLaboratoryDr. Louis A. Kaplan, Stroud Water ResearchCenter Streams transport and process particulate organic carbon (...

This paper describes work in progress for the development of a gestural controller interface for contemporary vocal performance and electronic processing. The paper includes a preliminary investigation of the gestures and movements of vocalists who use microphones and microphone stands. This repertoire of gestures forms the foundation of a well-practiced ‘language’ and social code for communica...

BACKGROUND AND OBJECTIVES Point-of-care (POC) ultrasound is increasingly used by clinicians across multiple medical specialties. Current perceptions and prevalence of POC ultrasound practice and training in family medicine residency programs has not been described. METHODS Questions were included in the 2014 Council of Academic Family Medicine Educational Research Alliance (CERA) survey of fa...