The objective of this study is to investigate the relationship between the hepatotoxicity induced by Polygoni Multiflori Radix (PMR, root of Polygonum multiflorum Thunb., He Shou Wu) and the activity of CYP1A2 or CYP2E1 in the rat liver. Levels of rat serum transaminases ALT and AST were not altered but the activity of CYP1A2 or CYP2E1 in the rat liver was significantly inhibited after oral adm...

BACKGROUND The optimal surgical treatment in functional ischemic mitral regurgitation (FIMR) remains controversial. Recently, a posterior papillary muscle relocation (PMR) technique as adjunct procedure to ring annuloplasty has been proposed to prevent recurrent FIMR. In the present study, we used 3D cardiac MRI to assess the impact of relocating both papillary muscles as adjunct procedure to d...

Polymyalgia rheumatica (PMR) affects older people, and although glucocorticoids are effective in treating PMR, they frequently result in side effects. Therefore, we conducted a retrospective study to assess the effectiveness and safety of tocilizumab as an alternative to glucocorticoids. We included 13 consecutive patients with PMR (11 women and 2 men; median age, 74 years) diagnosed according ...

SIR, The aetiology and pathogenesis of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are unknown. The cellular inflammation and immunoglobulin deposition in temporal artery biopsy specimens,' 2 and the dramatic clinical response to steroids suggest that an immunological abnormality might be associated with the pathogenesis of GCA or PMR. Two patients with serum monoclonal IgM and ...

BACKGROUND Patients with refractory angina have significant morbidity. This study aimed to compare two of the treatment options, Spinal Cord Stimulation (SCS) and Percutaneous Myocardial Laser Revascularisation (PMR) in terms of clinical outcomes and cost-effectiveness. METHODS Eligible patients were randomised to PMR or SCS and followed up for exercise tolerance time (ETT), Canadian Cardiova...

Until now, there have been no published researches evaluating referrals from family doctors (FDs) or utilizations of physical medicine and rehabilitation (PMR) in Croatia. The main study aim was of determining the referral trend and the trends in the number of PMR consultations. The data were collected from the Croatian Health Statistics Yearbook, 1995-2012. The results of this study pointed ou...

INTRODUCTION The present study was designed to clarify whether the bilateral cooperation in the human periodontal-masseteric reflex (PMR) differs between central incisors and canines. METHODS Surface array electrodes were placed on the bilateral masseter muscles to simultaneously record the firing activities of single motor units from both sides in seven healthy adults. During light clenching...

In 1964, US Supreme Court Justice Potter Stewart, a master of words, when trying to define hardcore pornography admitted, “I could never succeed in intelligibly doing so, but I know it when I see it. . . .” Polymyalgia rheumatica (PMR) has been in that sense the pornography of rheumatic diseases—a difficult to define syndrome of inflammatory pain and stiffness in older people, but one commonly ...

This study determines the perinatal mortality rate (PMR) among births recorded at the Women's Patna Medical College Hospital (PMCH) in India, and from other centers in the Patna district community, where the ICDS program was not implemented. Births include all infants over 28 weeks of gestational development and who weighed over 1000 g at birth. Infants were grouped by birth weights as follow...

BACKGROUND Papillary muscle rupture (PMR) is a rare, but often life-threatening mechanical complication of myocardial infarction (MI). Immediate surgical intervention is considered the optimal and most rational treatment for acute PMR, but carries high risks. At this point it is not entirely clear which patients are at highest risk. In this study we sought to determine in-hospital mortality and...