نتایج جستجو برای: pmn

تعداد نتایج: 3528  

Journal: :The American journal of physiology 1999
Sharon Rounds Laura L Likar Elizabeth O Harrington K Chul Kim Anthony Smeglin Karen Heins Nancy Parks

Accumulation of intraluminal polymorphonuclear leukocytes (PMN) is a hallmark of inflammatory diseases of the airways. Extracellular nucleotides stimulate PMN adhesion to human main pulmonary artery endothelial cells (HPAEC) by a purinoceptor-mediated mechanism. We investigated the effects of nucleotides on adhesion of freshly isolated human PMN to cultured human tracheobronchial epithelial cel...

Journal: :Infection and immunity 2002
Helmut Laufs Kerstin Müller Jens Fleischer Norbert Reiling Nicole Jahnke Jens C Jensenius Werner Solbach Tamás Laskay

The role of polymorphonuclear neutrophil granulocytes (PMN) in defense against the intracellular parasite Leishmania is poorly understood. In the present study, the interaction of human PMN with Leishmania major promastigotes was investigated in vitro. In the presence of fresh human serum, about 50% of PMN phagocytosed the parasites within 10 min and the parasite uptake led to PMN activation, r...

Journal: :The Journal of clinical investigation 1993
S P Colgan C N Serhan C A Parkos C Delp-Archer J L Madara

Neutrophil (PMN) migration across intestinal epithelial barriers, such as occurs in many disease states, results in modifications in epithelial barrier. Here, we investigated the impact of lipoxin A4 (LXA4), an eicosanoid with counterregulatory inflammatory roles, on PMN migration across cultured monolayers of the human intestinal epithelial cell line T84. Transepithelial migration of PMN was a...

Journal: :Mediators of Inflammation 1996
N. Van Osselaer M. Rampart A. G. Herman

The selectin-mediated rolling of leukocytes along the endothelial cells is a prerequisite step followed by firm adhesion and extravasation into the inflamed tissue. This initial contact can be suppressed by sulphated polysaccharides. We have studied the effect of sulphated polysaccharides on the ultimate polymorphonuclear leukocyte (PMN) recruitment and plasma leakage in rabbit skin in response...

Journal: :Journal of immunology 2007
Kol A Zarember Janyce A Sugui Yun C Chang Kyung J Kwon-Chung John I Gallin

Aspergillus fumigatus, a common mold, rarely infects humans, except during prolonged neutropenia or in cases of chronic granulomatous disease (CGD), a primary immunodeficiency caused by mutations in the NADPH oxidase that normally produces fungicidal reactive oxygen species. Filamentous hyphae of Aspergillus are killed by normal, but not CGD polymorphonuclear leukocytes (PMN); however, the few ...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Sharmila Choudhury Michael R Wilson Michael E Goddard Kieran P O'Dea Masao Takata

Polymorphonuclear leukocytes (PMN) play an important role in ventilator-induced lung injury (VILI), but the mechanisms of pulmonary PMN recruitment, particularly early intravascular PMN sequestration during VILI, have not been elucidated. We investigated the physiological and molecular mechanisms of pulmonary PMN sequestration in an in vivo mouse model of VILI. Anesthetized C57/BL6 mice were ve...

Journal: :Blood 1999
M Nakagawa G P Bondy D Waisman D Minshall J C Hogg S F van Eeden

When active bone marrow release is induced by inflammatory stimuli, it is associated with an increase in L-selectin expression on circulating polymorphonuclear leukocyte (PMN). This contrasts sharply with glucocorticoid-induced granulocytosis that is associated with decreased L-selectin expression on PMN. The present study was designed to determine if the reduced L-selectin expression observed ...

Journal: :Journal of immunology 1998
B Bussolati F Mariano A Cignetti A Guarini V Cambi R Foà G Piccoli G Camussi

IL-12 is chemotactic for NK cells and polymorphonuclear neutrophils (PMN), but not for monocytes. In the present study, we evaluated whether the chemotactic effect of IL-12 is a direct phenomenon or is dependent on the generation of secondary mediators. The results obtained indicate that IL-12 induces a dose- and time-dependent synthesis of platelet-activating factor (PAF) from PMN and NK cells...

Journal: :Journal of immunology 2009
Jamie Schwartz Kevin G Leidal Jon K Femling Jerrold P Weiss William M Nauseef

Successful host defense against bacteria such as Staphylococcus aureus (SA) depends on a prompt response by circulating polymorphonuclear leukocytes (PMN). Stimulated PMN create in their phagosomes an environment inhospitable to most ingested bacteria. Granules that fuse with the phagosome deliver an array of catalytic and noncatalytic antimicrobial peptides, while activation of the NADPH oxida...

Journal: :Blood 1992
N Maugeri V Evangelista P Piccardoni G Dell'Elba A Celardo G de Gaetano C Cerletti

Human polymorphonuclear leukocytes (PMN) activated by n-formyl-methionyl-leucyl-phenylalanine (fMLP), in the presence of cytochalasin B, are able to induce activation of coincubated autologous platelets "via" cathepsin G released from the azurophilic granules. However, thromboxane (Tx) B2 production in this system cannot be completely explained by cathepsin G-stimulated platelet arachidonate me...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید