Streptococcus pneumoniae accounts for more deaths worldwide than any other single pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. Life-threatening acute cardiac complications are more common in pneumococcal infection compared to other bacterial infections. Distinctively, these arise despite effective antibiotic therapy. Here, we describe a novel mecha...

This study investigates the time-dependent long-term creep strain in a composite cylinder made of glass/vinylester with a unidirectional ply. The cylinder is subjected to an internal pressure and the boundary condition is free–free and acts as thermal insulation. The classical lamination theory (CLT) is used to derive the governing equations as a second-order equation to determine the radial, c...

Streptococcus pneumoniae is the causative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis. Pneumolysin (Ply), a member of the cholesterol-dependent cytolytic pore-forming toxins, is produced by virtually all clinical isolates of S. pneumoniae, and strains in which the Ply gene has been deleted are severely attenuated in mouse models of infection. In con...

The free edges of layered structures require special attention in design processes. Due to the discontinuous material properties, singular stress concentrations occur where layer interfaces meet edge. These bi-material points have be closely examined as possible starting for delamination In present study, we propose an efficient approximate closed-form method analyze interlaminar shear stresses...

This report discusses the development and application of two alternative strategies in the form of global and sequential local response surface (RS) techniques for the solution of reliability-based optimization (RBO) problems. The problem of a thin-walled composite circular cylinder under axial buckling instability is used as a demonstrative example. In this case, the global technique uses a si...

We consider the recently introduced model of low ply graph drawing, a straight-line drawing in which the ply-disks of the vertices do not have many common overlaps, which results in a good distribution of the vertices in the plane. The ply-disk of a vertex is the disk centered at it whose radius is half the length of its longest incident edge. We focus our attention on low-ply drawings of trees...