The aim of the present study was to investigate the erythrocyte levels of lipid peroxidation (MDA), and antioxidant enzyme activities in Frund’s complete adjuvant (FCA) induced arthritis in rats. . Group I serves as normal. Group II to IV served as arthritis animals induced by FCA. Group III and IV treated with ultrasound and phonophoresis (Application of ultrasound along with Plumbago zeylanic...

BACKGROUND The extracts of Plumbago zeylanica have been used in China and other Asian countries as folk medicine for the treatment of cancer, rheumatoid arthritis and dysmenorrhoea. Effect of Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) purified from Plumbago zeylanica on Con A induced T cell proliferation was studied in spleen cells from collagen induced arthritic DBA/1 mice. METHODS Th...

A particulate enzyme system from Micrococcus roseus R2J has been obtained which catalyzes the biosynthesis of a peptidoglycan. The preparation catalyzes the incorporation of L-threonine onto the e-amino group of lysine in the presence of transfer RNA @RNA), supernatant solution, and ATP. Crude l%-L-threonyl-tRNA will substitute for these additional requirements. The threonyl-tRNAs of this organ...

Knowledge on the biosynthetic pathways of the monoterpene alkaloids is enormous, but little is known about their mechanism of transporting system from the plant cell. There is not concrete evidence confirming the role of ABC transporters in the secretion of monoterpene indole alkaloids (MIAs) in Catharanthus roseus. Therefore, in order to determine the role of different transporting systems inv...

Free radicals play an important role in pathological processes such as aging and developing cancer; hence, natural products inhibit free radical production, and can play an important role in preventing diseases. We aimed to evaluate the scavenging activity of free radicals, reducing power, inhibition of lipid peroxidation and malondialdehyde (MDA) formation, and the antioxidant composition of r...

In India, native remedies have been used in diabetes treatment. Plants have always been an ideal source of drugs and many of the plants either directly or indirectly are used to formulate the present available drugs. The present investigation was to find out the antihyperglycemic and antihyperlipidaemic effects of ethanolic leaves extracts of Catharanthus roseus in normal and streptozotocin (ST...

Antitumor substances related to vinblastine and vincristine are exclusively found in the Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family, and continue to be extensively used in cancer chemotherapy. Although in high demand, these valuable compounds only accumulate in trace amounts in C. roseus leaves. Vinblastine and vincristine are condensed from the monote...

The anti-oxidant activity and total phenolic content of alcoholic extracts from seven medicinal plants (Asparagus racemosus, Ocimum sanctum, Cassia fistula, Piper betel, Citrus aurantifolia, Catharanthus roseus, and Polyalthia longifolia) were evaluated by using a model system consisting of β-carotene, DPPH free radical and Folin-Ciocalteu method. The total Phenolic content of the extracts was ...

Plants deploy distinct secondary metabolisms to cope with environment pressure and to face bio-aggressors notably through the production of biologically active alkaloids. This metabolism-type is particularly elaborated in Catharanthus roseus that synthesizes more than a hundred different monoterpene indole alkaloids (MIAs). While the characterization of their biosynthetic pathway now reaches co...

Aranorosin, a new antifungal antibiotic, has been isolated from the culture filtrate and mycelium of a strain of Pseudoarachniotus roseus Kuehn. The antibiotic, C23H33NO6, contains a novel 1-oxaspiro[4,5]decane ring system. The structure (I) has been elucidated on the basis of spectroscopic and chemical analysis.