OBJECTIVE To prospectively analyze the prognostic factors for neurological complications of childhood bacterial meningitis. METHODS This prospective study enrolled 77 children from 1 month until 16 years of age, treated for bacterial meningitis during the period of January 1, 2009 through December 31, 2010. 16 relevant predictors were chosen to analyze their association with the incidence of ...

Candida albicans meningitis was induced in normal dogs and in dogs rendered neutropenic (<500/cu mm) in order to follow cerebrospinal fluid (CSF) granulocyte migration patterns, quantitative fungal cultures. and clinical events. Dogs received an intrathecal challenge with i07 C. albicans, and CSF samples were monitored. Neutropenia was produced by administration of cyclophosphamide 5 days befor...

A toxic syndrome characterized by fever, headache, and vomiting, lasting 2-5 days, occurred in 61% of 39 children with acute leukemia in complete remission, receiving central nervous system prophylaxis with intrathecal methotrexate, and in 14% of 34 children receiving the same plus cranial radiation. The syndrome was accompanied by pleocytosis with lymphocytes, monocytoid cells, and neutrophils...

BACKGROUND In the USA, Mycobacterium tuberculosis infection is more likely to be found in foreign-born individuals, and those co-infected with human immunodeficiency virus (HIV) are more likely to have tuberculous meningitis. The literature is lacking in details about the clinical workup of patients presenting with tuberculous meningitis with encephalopathic features who are co-infected with HI...

A 75-year-old healthy woman developed uveitis and chorioretinal infiltrates OD compatible with reticulum cell sarcoma. She was admitted to hospital 18 months later with somnolence and confusion. Examination revealed diffuse white matter hypodensity on computed tomography and a persistent cerebrospinal fluid pleocytosis. At necropsy reticulum cell sarcoma was found in the right globe and Aspergi...

Encephalitis is caused by multiple organisms, but rarely by the hepatitis A virus. A 27-year-old man visited our hospital because of fever, altered consciousness, and seizures. On physical exam, a stuporous mentality and neck stiffness were found. On laboratory exam, elevated liver enzymes and cerebrospinal fluid abnormalities, including pleocytosis and elevated protein levels were observed. Th...

A 27-year-old Puerto Rican man presented to Yale-New Haven Hospital with a six-week history of left-sided headache, diplopia, and drooping of the left side of his face. Cerebrospinal fluid examination showed a lymphocytic pleocytosis and a CT scan of the brain revealed an unusual intrapontine mass lesion requiring systemic antifungal therapy. This case emphasizes many of the diagnostic and ther...

Clinical features of 18 patients with either lymphocytic meningoradiculitis (n = 17) or chronic encephalomyelitis (n = 1) due to Borrelia burgdorferi are reported. Arthropod bites were recorded in only seven patients. High titres of anti B burgdorferi antibodies were detected in sera from all patients and in CSF from 12 out of 17 patients tested. All patients had CSF abnormalities especially pl...

Background: Lymphoma of the central nervous system (CNS), both primary and secondary, represents a very rare part patients with non-Hodgkin lymphoma. Methods: Exams included neurological exam, laboratory blood tests, МRI, biopsy, electromyography. Results: Three different clinical cases lymphoma are presented. The first patient is 44-year-old male admitted to emergency room because neck stiffne...