Cisplatin and its analogues are first-line chemotherapeutic agents for the treatment of numerous human cancers. A major inconvenience in their clinical use is their strong tendency to link to sulfur compounds, especially in kidney, ultimately leading to severe nephrotoxicity. To overcome this drawback we prepared a variety of platinum complexes with sulfur ligands and analyzed their biological ...

Metal-assisted chemical etching of silicon is an electroless method that can produce porous silicon by immersing metal-modified silicon in a hydrofluoric acid solution without electrical bias. We have been studying the metal-assisted hydrofluoric acid etching of silicon using dissolved oxygen as an oxidizing agent. Three major factors control the etching reaction and the porous silicon structur...

In recent years, more and more biochemists and pharmacologists have paid their attention to research on other transition metal complexes such as ruthenium (II), copper (II), zinc (II), nickel (II), cobalt (II) complexes compared with traditional platinum compounds in treatment of human cancer due to their potential applications as chemical and stereoselective probes of nucleic acid structures a...

Materials that are strong at progressively higher temperatures are sought for use in aircraft engines, in order that operating temperatures, and thereby efficiency and performance, can be increased. Intermetallic compounds with high melting temperatures have the promise of higher strength and elastic stiffness while hot, but in most cases they suffer from extreme brittleness at room temperature...

Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum compounds, such carcinomas eventually develop platinum resistance. Previously, we showed that acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. Here, we show that secondary mutations of BRCA1 also occu...

Alkene hydrosilylation, the addition of a silicon hydride (Si-H) across a carbon-carbon double bond, is one of the largest-scale industrial applications of homogeneous catalysis and is used in the commercial production of numerous consumer goods. For decades, precious metals, principally compounds of platinum and rhodium, have been used as catalysts for this reaction class. Despite their widesp...

Chapter 21 Phosphate-metal ion interactions of nucleotides and polynucleotides, by C. Klevickis and C. Grisham Sugar-metal ion interactions, by S. Yano and M. Otsuka Dichotomy of metal ion binding to N 1 and N7 of purines, by R. B. Martin General conclusions from solid state studies of nucleotide-metal ion complexes, by K. Aoki Solution structures of nucleotide-metal ion complexes. Isomeric equ...

Copper transporter 1 (CTR1) is a transmembrane protein that imports copper(i) into yeast and mammalian cells. Surprisingly, the protein also mediates the uptake of platinum anticancer drugs, e.g. cisplatin and carboplatin. To study the effects of several metal-binding residues/motifs of hCTR1 on the transport of both Cu(+) and cisplatin, we have constructed Hela cells that stably express a seri...