نتایج جستجو برای: platinum iv complexes

تعداد نتایج: 330620  

Journal: :Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2013
V Volarevic J M Vujic M Milovanovic T Kanjevac A Volarevic S R Trifunovic N Arsenijevic

PURPOSE As novel therapeutic agents relevant to colon cancer therapy are explored continuously, we tested 4 R2edda-type ligand precursors O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid (L1.2HCl-L4.2HCl) and corresponding palladium(II) and platinum(II) complexes against the human colon cancer cell lines CaCo-2, SW480 and HCT116. METHODS The effects of the teste...

2003
M. Georgieva

The electrochemical behavior of Pt(IV) ions in the presence of dimethylglyoxime has been investigated using adsorptive stripping voltammetric method. The results indicated that the platinum is reduced from its adsorbed state as bis-dimethylglyoxi-mate platinum(IV) complex. The peak current is linearly proportional to the Pt(IV) concentration in the solution, thus representing the basis for a qu...

Journal: :Nanoscale 2012
Michele Iafisco Barbara Palazzo Gianmario Martra Nicola Margiotta Sara Piccinonna Giovanni Natile Valentina Gandin Cristina Marzano Norberto Roveri

In the present study two nanocrystalline apatites have been investigated as bone-specific drug delivery devices to be used for treatment of bone tumors either by local implantation or by injection. In order to assess how the Ca/P ratio can influence the adsorption and release of anticancer platinum-bisphosphonate complexes, two kinds of apatite nanocrystals having different Ca/P ratios but simi...

Journal: :Chemistry, an Asian journal 2010
Ping Wang Chung-Hang Leung Dik-Lung Ma Wei Lu Chi-Ming Che

Platinum(II) complexes bearing acetylide ligands containing nucleobase motifs are prepared and their impact on human topoisomerase II (TopoII) is evaluated. Both platinum(II) complexes [Pt(II)(C^N^N)(C≡CCH₂R)] (1a-c) and [Pt(II)(tBu₃terpy)(C≡CCH₂R)](+) (2a-c) (C^N^N=6-phenyl-2,2'-bipyridyl, tBu₃terpy=4,4',4''-tri-tert-butyl-2,2':6',2''-terpyridyl, and R=(a) adenine, (b) thymine, and (c) 2-amino...

2005
H. Chisholm

Historically, platinum has played a prominent role in organometallic chemistry. The compounds KPtCI,(C,H,)H,O (I), PtMe, (X) (2) and Chugaev's salt [PtC,H,,N,],Clx (3, 4) present some of the fist examples of stable metal-olefin, metal-alkyl and metalcarbene complexes, although ironically the nature of the bonding in these compounds was not immediately recognised. In the study of organometallic ...

Journal: :Dalton transactions 2015
Hugo Sesolis Jamal Moussa Geoffrey Gontard Anny Jutand Maria Pia Gullo Andrea Barbieri Hani Amouri

A unique class of neutral cyclometalated platinum(ii) complexes with π-bonded benzenedithiolate are reported including two X-ray molecular structures. To the best of our knowledge these are the first structures to be reported for cyclometalated platinum complexes with a benzenedithiolate ligand. All of the complexes are luminescent in fluid solution at room temperature and in frozen solvent gla...

Journal: :BMC Biotechnology 2009
Zhongyu Lin Ru Xue Yiwen Ye Jianhong Zheng Zhenling Xu

BACKGROUND Platinum nanomaterial is one of the significant noble metal catalysts, and the interaction of platinum with microbe is one of the key factors in influencing the size and the distribution of the platinum nanoparticles on the microbial biomass. Some properties of Pt(IV) adsorption and reduction by resting cells of Bacillus megatherium D01 biomass have once been investigated, still the ...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2008
Dirk Garmann André Warnecke Ganna V Kalayda Felix Kratz Ulrich Jaehde

The development of resistance is one of the major limitations for the use of platinum (Pt) complexes in cancer chemotherapy. As reduced cellular uptake is a well-known resistance mechanism of cisplatin we explored the potential to overcome resistance in cisplatin-resistant A2780 ovarian carcinoma cells by means of macromolecular prodrugs exploiting endocytosis as alternative uptake mechanism. T...

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2002
Ki-Min Park Il Yoon U-Hyon Paek Shim Sung Lee Jin Beom Choi Jae-Kyung Yang Bong Gon Kim

there has been a considerable interest in platinum group metal complexes of thiaoxa-donor macrocycles because of their unusual properties. 1 As an extension of our studies involving mixed-donor cyclic 2a and acyclic 2b ligands incorporating thiaoxa mixed-donors, we became interested in exploring their coordination chemistry of platinum group metal ions. The S2O-donor macrocycle of the title com...

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