BACKGROUND Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a rea...

In a series of important studies Murphy and his colleagues demonstrated that the preparation and storage of platelet-rich plasma and platelet concentrates at 22°C rather than 4°C improved their life span in vivo (Murphy and Gardner, 1969; Murphy, Sayar, and Gardner, 1970). The potential clinical relevance of this finding has been confirmed by Handin and Valeri (1971), and it is likely that this...

Citrated platelet-rich plasma (PAP) was kept at cold temperatures or room temperature. After 4 hr or more at these temperatures, the PRPs were warmed 1 hr at 37#{176}C. This prevents the spontaneous aggregation seen in chilled PRP that is stirred immediately after warming. Platelet aggregation in response to connective tissue (CT), epinephrine, and adenosine diphosphate (ADP) was considerably g...

background: recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. we aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. methods: in vitro susceptibility to samples of 10 random human platelet concentrates was determine...

Concerns over bacterial proliferation in room temperature–stored platelet concentrates prompted the US Food and Drug Administration on June 02 1986 to issue a memorandum to blood establishments directing a reduction in the allowable storage time of platelet concentrates from 7 to 5 days. In this memorandum, the FDA called attention to several cases of fatal post-transfusion sepsis from platelet...