Platelet aggregation is the key process in primary hemostasis. Certain conditions such as hypoxia may induce platelet aggregation and lead to platelet sequestration primarily in the pulmonary microcirculation. We investigated the influence of high-altitude exposure on platelet function as part of a larger study on 30 subjects with a history of high-altitude pulmonary edema (HAPE) and 10 healthy...

Inhibition of platelet aggregation by acadesine was evaluated both in vitro and ex vivo in human whole blood using impedance aggregometry, as well as in vivo in a canine model of platelet-dependent cyclic coronary flow reductions. In vitro, incubation of acadesine in whole blood inhibited ADP-induced platelet aggregation by 50% at 240±60 ,IM. Inhibition of platelet aggregation was time dependen...

Based on the prodrug principle, aspirin eugenol ester (AEE) was synthesized, which can reduce the side effects of aspirin and eugenol. As a good candidate for new antithrombotic and anti-inflammatory medicine, it is essential to evaluate its preventive effect on thrombosis. Preventive effect of AEE was investigated in κ-carrageenan-induced rat tail thrombosis model. AEE suspension liquids were ...

Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet-platelet and platelet-vessel wall interactions, the aim of this study was to establish if antioxidant activity was responsible for the antiplatelet activity of succinobucol. Platelet aggregation in response to collagen and adenosine diphosphate (A...

The in vitro inhibitory effect of SR 27417, an antagonist of the platelet-activating factor (PAF) receptor, on PAF-induced platelet aggregation was studied in blood collected from seven healthy Friesien calves. Inhibitory effects of SR 27417 were determined at thirteen different concentrations (0.1-400 nM) by using the dose-response curves of PAF on calf platelet aggregation. In the presence of...

Introduction: Mild-to-moderate nausea and/or vomiting affects up to 80% of all pregnant women, usually peaking by week 9 and subsiding by week 20. For 9% to 20% of women, nausea and vomiting of pregnancy persist longer; Nausea and vomiting are complex responses involving various neural pathways and motor responses to sensory stimuli. Definition: Ginger, the rhizome of Zingiber officinale, is on...

Platelet aggregation velocity was moosured with an aggregometer in plateletrich plasma from 34 normal subjects following addition of ADP, collagen, or epinephrine. Platelet volume parameters [mean, mode, megathrombocyte index (large platelets)] were determined with a model B Coulter Counter attached to a P64 Channel Analyzer with electronic recorder and correlated with platelet count. A negativ...