نتایج جستجو برای: plasma glucose and insulin concentrations

تعداد نتایج: 16943252  

Journal: :Clinical chemistry 2003
Pierre Allard Edgard E Delvin Gilles Paradis James A Hanley Jennifer O'Loughlin Claudette Lavallée Emile Levy Marie Lambert

BACKGROUND Plasma fasting insulin and the homeostasis model assessment of insulin resistance (HOMA-IR) are markers of IR, which, at least in part, mediates the relation of obesity to increased cardiovascular risk. Increased free fatty acids (FFAs) may be involved in the pathogenesis of IR. Our objectives were to describe the distributions of fasting plasma insulin, glucose, and FFAs and HOMA-IR...

Journal: :Archives of disease in childhood 1993
J M Hawdon A Aynsley-Green K Bartlett M P Ward Platt

Some neonates, such as those who are preterm or small for dates, become hypoglycaemic or hyperglycaemic. These disorders represent a failure of neonatal metabolic adaptation, but the underlying mechanisms are unclear. Data from studies of hypoglycaemic and hyperglycaemic infants were reviewed in the light of new data from studies of healthy neonates. Data from 28 neonates, who had disordered bl...

Journal: :American journal of physiology. Endocrinology and metabolism 2006
Marion A M den Boer Peter J Voshol Folkert Kuipers Johannes A Romijn Louis M Havekes

Insulin is an important inhibitor of both hepatic glucose output and hepatic VLDL-triglyceride (VLDL-TG) production. We investigated whether both processes are equally sensitive to insulin-mediated inhibition. To test this, we used euglycemic clamp studies with four increasing plasma concentrations of insulin in wild-type C57Bl/6 mice. By extrapolation, we estimated that half-maximal inhibition...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Masarsu Iwai Huan-Sheng Li Rui Chen Tetsuya Shiuchi Lan Wu Li-Juan Min Jian-Mei Li Masahiro Tsuda Jun Suzuki Yumiko Tomono Hirokazu Tomochika Masaki Mogi Masatsugu Horiuchi

The potential combined effect and mechanism of calcium channel blockers (CCB) and angiotensin II type 1 receptor blockers (ARB) to improve insulin resistance were investigated in type 2 diabetic KK-Ay mice, focusing on their antioxidative action. Treatment of KK-Ay mice with a CCB, azelnidipine (3 mg/kg/day), or with an ARB, olmesartan (3 mg/kg/day), for 2 weeks lowered the plasma concentration...

2010
Stefan Lindpointner Stefan Korsatko Gerd Köhler Hans Köhler Roland Schaller Ruthy Kaidar Ofer Yodfat Lukas Schaupp Martin Ellmerer Thomas R. Pieber Werner Regittnig

OBJECTIVE To simplify and improve the treatment of patients with type 1 diabetes, we ascertained whether the site of subcutaneous insulin infusion can be used for the measurement of glucose. RESEARCH DESIGN AND METHODS Three special indwelling catheters (24-gauge microperfusion [MP] catheters) were inserted into the subcutaneous adipose tissue of subjects with type 1 diabetes (n = 10; all C-pep...

Journal: :The American journal of clinical nutrition 2009
Jerry R Greenfield I Sadaf Farooqi Julia M Keogh Elana Henning Abdella M Habib Anthea Blackwood Frank Reimann Jens J Holst Fiona M Gribble

BACKGROUND Incretin hormones, such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play an important role in meal-related insulin secretion. We previously demonstrated that glutamine is a potent stimulus of GLP-1 secretion in vitro. OBJECTIVE Our objective was to determine whether glutamine increases circulating GLP-1 and GIP concentrations in vivo a...

Amniattalab, Amir, Azimzadeh, Kaveh, Golam Mohebbi, Reza,

This study aimed to assess whether the triethylenetetramine (TETA) is impressed the plasma level of homocysteine (Hcy), total sialic acid (TSA) and cardiac troponin I (cTnI) as cardiovascular diseases risk factors, cystatin c (Cys c) and glucose along with histopathologic changes in alloxan induced diabetes mellitus in rabbit. Twenty number New Zealand white rabbits were assigned for this study...

2010
Jenny Tong Ronald L. Prigeon Harold W. Davis Martin Bidlingmaier Steven E. Kahn David E. Cummings Matthias H. Tschöp David D'Alessio

OBJECTIVE The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. The goal of this study was to test the hypothesis that circulating ghrelin suppresses glucose-stimulated insulin secretion in healthy subjects. RESEARCH DESIGN AND METHODS Ghre...

Abbas Ghanbari-Niaki , Ahmad Abdi, Asieh Abbasi, Mandana Gholami,

Introduction: Visfatin is predominantly secreted from visceral adipose tissue and mimics the effect of insulin by binding to insulin receptors. The purpose of the present research is to examine the effect of glucose intake on plasma visfatin concentration following an aerobic exercise session. Methods: In a quasi-experimental study, 16 male non-athlete students (21.91±2.31 yrs., 77.53...

Journal: :iranian journal of basic medical sciences 0
azar hosseini pharmacological research centre of medicinal plants, department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran reza shafiee-nick pharmacological research centre of medicinal plants, department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran nasser pour ali behzad pharmacological research centre of medicinal plants, department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran hamid sadeghian pharmacological research centre of medicinal plants, department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

objective(s) pde3 has a functional role in insulin secretion and action. we investigated the metabolic effects of new synthetic pde3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. materials and methods the test compound or solvent was injected subcutaneously to mice, for 7 days. on day 8, blood and liver samples were obtained. in hyperglycemic rat, 0.5 g/kg glucose with or w...

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