In normal fasted rats whole liver tissue contains as much glucose as the blood plasma, i.e., the ratio of the concentrations is about unity. The concentration of glucose in hepatic intracellular water is about 1.2 times higher than in plasma water. In rats injected with insulin the concentration of glucose in the liver falls to a lesser extent than in the plasma: resulting in a ratio of concent...

We examined the intracellular metabolic fate of plasma glucose during a hyperglycemic clamp in impaired glucose-tolerant (IGT; n = 21) and normal glucose-tolerant subjects (n = 10) using a combination of [3-(3)H]glucose infusion with measurement of [(3)H]water formation and indirect calorimetry. IGT was associated with approximately 35% reduced first-phase insulin responses, normal second-phase...

OBJECTIVE To assess the relative contribution of increased fasting and postload plasma glucose concentrations to the incidence of type 2 diabetes in subjects with a normal 2-h plasma glucose concentration. RESEARCH DESIGN AND METHODS A total of 3,450 subjects with 2-h plasma glucose concentration <140 mg/dl at baseline were followed up in the San Antonio Heart Study (SAHS) and the Botnia Study ...

visfatin is a newly discovered adipokine which increases along with obesity. it is not clear whether rhythmic aerobic endurance exercise training which induces changes in adipose tissue and blood lipid might decrease the plasma visfatin level. the aim of this study was to examine the effect of rhythmic aerobic endurance exercise training on rest visfatin levels some metabolic risk factors in ob...

Resistance to insulin-mediated glucose disposal has been previously shown to be increased in association with obesity, high blood pressure, and non-insulin-dependent diabetes mellitus. We initiated the present study to quantify the separate effects of hypertension and non-insulin-dependent diabetes mellitus on insulin resistance in both nonobese and obese subjects. To accomplish this, 88 subjec...

OBJECTIVE To test the hypothesis that glucose ingestion leads to a decrease in plasma ionized calcium (iCa) and ionized magnesium (iMg) during the third trimester of pregnancy. METHODS We studied 54 women who underwent a 50 g glucose challenge test (GCT) and 27 women who underwent a 3-hour 100 g glucose tolerance test (GTT) because of an abnormal GCT. Plasma glucose was measured with an autom...

CONTEXT Control of plasma glucose could prevent the progression of most of the complications of diabetes and hemoglobinA1c (HbA1c) is the most important criterion controlling these long-term complications. AIMS This study was performed to assess the effect of fasting plasma glucose (FPG) and two- hour postprandial plasma glucose (2hpp) levels on HbA1c. MATERIALS AND METHODS In this descript...

BACKGROUND dehydro-epiandrosterone sulphate (DHEAS) has been reported to ameliorate diabetes mellitus in rats. AIM we investigated the relationships between plasma glucose, age, serum DHEAS and weight in healthy men. METHODS we measured the serum DHEAS, fasting plasma glucose, plasma cortisol and body mass index in 169 subjects (mean age 46.5 years). RESULTS there was a significant declin...

The concentrations of plasma glucose, free fatty acids, insulin, growth hormone, and placental prolactin in subhuman primate fetal and maternal plasma were examined following intravascular administration of insulin and glucagon to the fetus and mother. The neonatal plasma responses to these same stimuli were also examined. Fetal plasma glucose concentrations were minimally altered by direct fet...